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World J Virol. Nov 25, 2021; 10(6): 301-311
Published online Nov 25, 2021. doi: 10.5501/wjv.v10.i6.301
Impact of COVID-19 on liver disease: From the experimental to the clinic perspective
Sheila Gato, Ana Lucena-Valera, Rocío Muñoz-Hernández, José Manuel Sousa, Manuel Romero-Gómez, Javier Ampuero
Sheila Gato, Rocío Muñoz-Hernández, Manuel Romero-Gómez, Javier Ampuero, SeLiver Group, Instituto de Biomedicina de Sevilla, Sevilla 41013, Spain
Ana Lucena-Valera, José Manuel Sousa, Manuel Romero-Gómez, Javier Ampuero, Digestive Department, Hospital Universitario Virgen del Rocio, Sevilla 41013, Spain
Rocío Muñoz-Hernández, Manuel Romero-Gómez, Javier Ampuero, University of Seville, Sevilla 41013, Spain
Author contributions: Ampuero J conceived and designed the review; Muñoz-Hernández R, and Sousa JM collected data from the literature; Gato S, and Lucena-Valera A drafted the manuscript; Ampuero J and Romero-Gómez MR critically revised the manuscript.
Conflict-of-interest statement: No conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Javier Ampuero, MD, MSc, PhD, Doctor, Professor, Senior Scientist, Digestive Department, Hospital Universitario Virgen del Rocio, Avda. Manuel Siurot s/n, Sevilla 41013, Spain. javi.ampuero@gmail.com
Received: March 24, 2021
Peer-review started: March 24, 2021
First decision: May 5, 2021
Revised: May 18, 2021
Accepted: August 13, 2021
Article in press: August 13, 2021
Published online: November 25, 2021
Processing time: 242 Days and 11.3 Hours
Abstract

Coronavirus disease 2019 (COVID-19) has caused a global pandemic unprecedented in over a century. Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a predominantly respiratory infection, various degrees of liver function abnormalities have been reported. Pre-existing liver disease in patients with SARS-CoV-2 infection has not been comprehensively evaluated in most studies, but it can critically compromise survival and trigger hepatic decompensation. The collapse of the healthcare services has negatively impacted the diagnosis, monitoring, and treatment of liver diseases in non-COVID-19 patients. In this review, we aim to discuss the impact of COVID-19 on liver disease from the experimental to the clinic perspective.

Keywords: SARS-CoV-2; COVID 19; Liver disease; Transaminases

Core Tip: The outbreak of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed a critical threat to global public health. Beyond the respiratory symptoms, some patients with COVID-19 show liver damage. In this scenario, it has been suggested that there might be a specific relationship between SARS-CoV-2 infection and liver injury.