Case Report
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Aug 24, 2017; 7(4): 243-249
Published online Aug 24, 2017. doi: 10.5500/wjt.v7.i4.243
De novo intraocular amyloid deposition after hepatic transplantation in familial amyloidotic polyneuropathy
Ivo Filipe Gama, Leonor Duarte Almeida
Ivo Filipe Gama, Leonor Duarte Almeida, Ophthalmology Department, Santa Maria University Hospital (North Lisbon Hospital Center), 1649-035 Lisbon, Portugal
Author contributions: Gama IF and Almeida LD designed the report; Almeida LD evaluated and followed-up the patient; Gama IF performed the complimentary exams and collected all clinical data; Gama IF and Almeida LD wrote the paper.
Institutional review board statement: The retrospective review and publication of patient’s clinical data were approved by the Santa Maria University Hospital Ethics Committee.
Informed consent statement: The patient gave written consent for publication of his clinical data.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest to disclose and they did not receive any funding for this paper.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Ivo Filipe Gama, MD, Ophthalmology Department, Santa Maria University Hospital (North Lisbon Hospital Center), Av. Prof. Egas Moniz, 1649-035 Lisbon, Portugal.
Telephone: +351-93-9160876
Received: September 15, 2016
Peer-review started: September 17, 2016
First decision: October 21, 2016
Revised: May 29, 2017
Accepted: June 19, 2017
Article in press: June 20, 2017
Published online: August 24, 2017
Core Tip

Core tip: Ocular manifestations of familial amyloidotic polyneuropathy (FAP) can appear after liver transplantation due to de novo ocular production of amyloid. Rarely, amyloid deposition in vitreous is relatively less exuberant than in anterior segment. Our case illustrates this asymmetry of amyloid deposition and emphasizes the association between scalloped pupils and glaucoma, a major ocular complication of FAP. Our case had a stable course, with excellent visual function and the intraocular pressure was controlled by medical therapy, which are unusual in this type of glaucoma. This case-report also highlights the importance of the long-term ophthalmological follow-up in FAP patients.