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World J Transplant. Nov 18, 2022; 12(11): 347-358
Published online Nov 18, 2022. doi: 10.5500/wjt.v12.i11.347
Challenges in liver transplantation in the context of a major pandemic
Eleni Theocharidou, Danielle Adebayo
Eleni Theocharidou, 2nd Department of Internal Medicine, Aristotle University of Thessaloniki, Konstantinoupoleos 49, 54642, Thessaloniki, Greece
Danielle Adebayo, Department of Gastroenterology and Hepatology, Royal Berkshire NHS Foundation Trust, London Road, Reading, RG1 5AN, United Kingdom
Author contributions: Theocharidou E reviewed the literature, wrote the paper and approved the final draft. Adebayo D reviewed the literature, critically revised the paper and approved the final draft.
Conflict-of-interest statement: All authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Eleni Theocharidou, PhD, 2nd Department of Internal Medicine, Aristotle University of Thessaloniki, Konstantinoupoleos 49, 54642, Thessaloniki, Greece. elenit@auth.gr
Received: June 9, 2022
Peer-review started: June 9, 2022
First decision: July 13, 2022
Revised: August 27, 2022
Accepted: September 22, 2022
Article in press: September 22, 2022
Published online: November 18, 2022
Core Tip

Core Tip: Coronavirus disease-2019 pandemic posed unprecedented challenges in terms of managing patients with advanced liver disease remotely, offering transplant for highly selected patients, managing immunosuppression, treating infected patients with chronic liver disease, transplanting infected patients, and utilizing grafts from infected donors. The transplant community responded rapidly to these challenges and many centers were able to resume activity soon after the first wave of the pandemic. Emerging data help shed light on areas of uncertainty and provide guidance for future challenges.