Systematic Reviews
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Mar 31, 2020; 10(3): 64-78
Published online Mar 31, 2020. doi: 10.5500/wjt.v10.i3.64
Novel alternative transplantation therapy for orthotopic liver transplantation in liver failure: A systematic review
Tomoaki Furuta, Kinji Furuya, Yun-Wen Zheng, Tatsuya Oda
Tomoaki Furuta, Kinji Furuya, Yun-Wen Zheng, Tatsuya Oda, Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba-shi 305-8575, Ibaraki, Japan
Yun-Wen Zheng, Institute of Regenerative Medicine and Affiliated Hospital of Jiangsu University, Zhenjiang 212001, Jiangsu Province, China
Yun-Wen Zheng, Department of Regenerative Medicine, School of Medicine, Yokohama City University, Yokohama 236-0004, Japan
Yun-Wen Zheng, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan
Author contributions: Furuta T conceptualized and designed the review together with Furuya K and Zheng YW; Furuta T and Furuya K carried out the analysis; Furuta T drafted the initial manuscript; all authors reviewed and approved the final manuscript as submitted; Furuta T and Furuya K contributed equally to the work; Zheng YW and Oda T are senior authors.
Supported by National Natural Science Foundation of China, No. 81770621; Ministry of Education, Culture, Sports, Science, and Technology of Japan, KAKENHI, No. 18H02866; and Japan Science and Technology Agency-Japan International Cooperation Agency's (JST-JICA) Science and Technology Research Partnership for Sustainable Development (SATREPS) Project, No. JPMJSA1506.
Conflict-of-interest statement: The authors report no relevant conflicts of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Yun-Wen Zheng, PhD, Associate Professor, Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Faculty of Medicine, University of Tsukuba, Tennodai 1-1-1, Tsukuba-shi 305-8575, Ibaraki, Japan.
Received: December 4, 2019
Peer-review started: December 4, 2019
First decision: December 12, 2019
Revised: February 10, 2020
Accepted: March 23, 2020
Article in press: March 23, 2020
Published online: March 31, 2020
Core Tip

Core tip: This systematic review analyzes the current status of transplantation treatments in place of liver organ transplantation from multiple viewpoints. We classified reports into three types: Xeno-organ transplantation, scaffold-based transplantation, and cell transplantation. Clinical application occurred for cell transplantation with hepatocytes and mesenchymal stem cells; however, the effect was limited. On the other hand, scaffold-based transplantation is a comprehensive treatment that combines organ transplantation and cell transplantation. Future research for clinical application is expected. The present article provides researchers with a summary and updated information on recent trends in alternatives to liver transplantation and support for future research.