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World J Rheumatol. Nov 12, 2014; 4(3): 44-53
Published online Nov 12, 2014. doi: 10.5499/wjr.v4.i3.44
Published online Nov 12, 2014. doi: 10.5499/wjr.v4.i3.44
Muscle wasting in rheumatoid arthritis: The role of oxidative stress
Antonios Stavropoulos-Kalinoglou, Charikleia Deli, Athanasios Z Jamurtas, Department of Sport and Exercise Science, University of Thessaly, 42100 Trikala, Greece
George D Kitas, Department of Rheumatology, Dudley Group NHS Foundation Trust, Russell’s Hall Hospital, Dudley, West Midlands DY1 2HQ, United Kingdom
George D Kitas, Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester M13 9PT, United Kingdom
Athanasios Z Jamurtas, Institute of Human Performance and Rehabilitation, Centre for Research and Technology Thessaly, 42100 Trikala, Greece
Author contributions: Stavropoulos-Kalinoglou A, Deli C, Kitas GD and Jamurtas AZ contributed to this paper.
Supported by The research project is implemented within the framework of the Action «Supporting Postdoctoral Researchers» of the Operational Program “Education and Lifelong Learning” (Action’s Beneficiary: General Secretariat for Research and Technology); and is co-financed by the European Social Fund (ESF) and the Greek State
Correspondence to: Antonios Stavropoulos-Kalinoglou, PhD, Department of Sport and Exercise Science, University of Thessaly, Trikala-Karyes Road, 42100 Trikala, Greece. antonios.stav@gmail.com
Telephone: +30-24-31047038 Fax: +30-24-31047038
Received: April 17, 2014
Revised: September 1, 2014
Accepted: September 23, 2014
Published online: November 12, 2014
Revised: September 1, 2014
Accepted: September 23, 2014
Published online: November 12, 2014
Core Tip
Core tip: Muscle wasting is common in rheumatoid arthritis (RA) and associates with significant health burden. To date several theories have been proposed to explain why RA patients loose muscle mass but the exact underlying mechanisms are not clear. Oxidative stress is a key driver of muscle wasting in the general population; however, its potential role in muscle wasting in RA has not been studied. As it arises from this review, oxidative stress seems to contribute to muscle wasting in RA. Further research on the subject is warranted, especially focusing on the underlying mechanisms and potential interventions.