Published online Nov 12, 2014. doi: 10.5499/wjr.v4.i3.44
Revised: September 1, 2014
Accepted: September 23, 2014
Published online: November 12, 2014
Core tip: Muscle wasting is common in rheumatoid arthritis (RA) and associates with significant health burden. To date several theories have been proposed to explain why RA patients loose muscle mass but the exact underlying mechanisms are not clear. Oxidative stress is a key driver of muscle wasting in the general population; however, its potential role in muscle wasting in RA has not been studied. As it arises from this review, oxidative stress seems to contribute to muscle wasting in RA. Further research on the subject is warranted, especially focusing on the underlying mechanisms and potential interventions.