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World J Rheumatol. Nov 12, 2014; 4(3): 35-43
Published online Nov 12, 2014. doi: 10.5499/wjr.v4.i3.35
Gender differences in axial spondyloarthritis
Regula Neuenschwander, Adrian Ciurea
Regula Neuenschwander, Adrian Ciurea, Department of Rheumatology, University Hospital Zurich, 8091 Zurich, Switzerland
Author contributions: Neuenschwander R and Ciurea A were involved in drafting the article and revising it critically for important intellectual content and English language; Both authors approved the final version to be published.
Correspondence to: Adrian Ciurea, MD, Department of Rheumatology, University Hospital Zurich, Gloriastrasse 25, 8081 Zurich, Switzerland.
Telephone: +41-44-2552932 Fax: +41-44-2554415
Received: July 11, 2014
Revised: August 18, 2014
Accepted: September 18, 2014
Published online: November 12, 2014
Core Tip

Core tip: In comparison to men, women with ankylosing spondylitis (AS) experience a higher subjective burden of disease despite lower objective signs of systemic inflammation and less spinal radiographic damage. A better response to treatment with tumor necrosis factor inhibitors has been demonstrated in male AS patients.