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World J Rheumatol. Jul 12, 2015; 5(2): 96-100
Published online Jul 12, 2015. doi: 10.5499/wjr.v5.i2.96
Ins and outs of Helicobacter pylori association with autoimmune rheumatic diseases
Jibran Sualeh Muhammad, Syed Faisal Zaidi, Muhammad Ishaq
Jibran Sualeh Muhammad, Department of Gastroenterology and Hematology, Faculty of Medicine, University of Toyama, Toyama 930-0914, Japan
Syed Faisal Zaidi, Department of Basic Medical Sciences, College of Medicine, King Saud bin Abdulaziz University of Health Sciences, Jeddah 21423, Saudi Arabia
Muhammad Ishaq, Department of Internal Medicine, Jinnah Medical College Hospital, Korangi, Karachi 74000, Pakistan
Author contributions: Muhammad JS designed research, performed research; wrote the paper; Zaidi SF and Ishaq M critically reviewed and corrected the manuscript; all authors have approved the final manuscript.
Conflict-of-interest statement: None.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Jibran Sualeh Muhammad, Department of Gastroenterology and Hematology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan. dr.jibran@live.com
Telephone: +81-80-42501703 Fax: +81-76-4345027
Received: November 6, 2014
Peer-review started: November 10, 2014
First decision: December 26, 2014
Revised: January 28, 2015
Accepted: March 30, 2015
Article in press: April 4, 2015
Published online: July 12, 2015
Abstract

Helicobacter pylori (H. pylori) infection is widely prevalent throughout worldwide. H. pylori manage a long-term survival in hostile environment of human stomach leading to peptic ulcer diseases and gastric cancer. But mostly infected person remains asymptomatic. Its chronic interaction with immune system makes H. pylori as an attractive candidate for the researchers to study its association with autoimmune diseases. This article presents a review of the literature on the association of H. pylori infection in selective autoimmune rheumatic diseases (RD). The authors used MeSH terms “Helicobacter pylori” with “rheumatoid arthritis,”“systemic lupus erythematosus,” or “fibromyalgia” to search PubMed database. All relevant studies identified were included. Despite extensive medical advancement many questions on role of H. pylori infection in autoimmune RD still remain unanswered. Further studies are therefore needed to address the role of H. pylori in pathogenesis of RD.

Keywords: Autoimmunity, Systemic lupus erythematosus, Rheumatoid arthritis, Fibromyalgia, Helicobacter pylori

Core tip:Helicobacter pylori (H. pylori) infection is widely prevalent throughout worldwide. Its chronic interaction with immune system makes H. pylori is an attractive candidate for the researchers to study its association with autoimmune disorders. This study presents a review of the literature on the H. pylori association with selective autoimmune rheumatic disorders. Despite extensive medical advancement many questions on the association of H. pylori infection with autoimmune rheumatic disorders still remain unanswered. More studies are therefore required to address the role of H. pylori infection in pathogenesis of rheumatic diseases.