Minireviews
Copyright ©The Author(s) 2022.
World J Psychiatry. Jul 19, 2022; 12(7): 884-896
Published online Jul 19, 2022. doi: 10.5498/wjp.v12.i7.884
Table 1 Summary of studies on main candidate genes of the glutamatergic system related to depression
Receptor
Gene
Marker
Ref.
Result
NMDAGRIN2Ars16966731Chen et al[79], 2021T allele associated with antidepressant effect of ketamine
GRIN2Brs1805502Zhang et al[69], 2014G allele associated with TRD
Arnold et al[70], 2009GT haplotype increased risk of TRD
rs890 Zhang et al[69], 2014C allele associated with TRD
Arnold et al[70], 2009
rs2268115 Sokolowski et al[72], 2013Associated with suicide attempts
rs220557Sokolowski et al[72], 2013Associated with suicide attempts
AMPAGRIA2rs4302506Chiesa et al[91], 2012C allele associated with a lower age of onset in MDD
rs4400397Chiesa et al[91], 2012C allele associated with a lower age of onset in MDD
GRIA3rs4825476Laje and McMahon[17], 2007G allele associated with suicidal ideation
KainateGRIK4 rs1954787Horstmann et al[94], 2010CC haplotype associated with response to antidepressants
Serretti et al[95], 2012No significant associations
rs12800734Horstmann et al[94], 2010GG haplotype associated with response to antidepressants
Serretti et al[95], 2012No significant associations