Observational Study
Copyright ©The Author(s) 2020.
World J Psychiatr. Jan 19, 2020; 10(1): 1-11
Published online Jan 19, 2020. doi: 10.5498/wjp.v10.i1.1
Table 1 Components of the Cognivue® quantitative assessment tool
Sub-battery and Sub-testDescription
Basic motor and visual ability
Adaptive motor control testAssesses visuomotor responsiveness using speed and accuracy measures
Measures subject’s ability to control the rotatory movement of the CogniWheel™ in response to rotational visual stimuli
Visual salience testAssesses basic visual processing functions
Measures the subject’s ability to identify a wedge filled by a random pattern of black and white dots shown on an neutral (gray) background
Perceptual processing
Letter discriminationMeasures the subject’s perceptual processing of different forms, despite the addition of increasing amounts of clutter
Discriminate real English letters from a variety of non-letter, letter-like shapes
Word discriminationAs above
Discriminate real 3-letter words from 3-letter non-words
Shape discriminationAs above
Discriminate a circle filled with a common shape from the rest of the display filled with other common shapes
Motion discriminationAs above
Discriminate a circle filled with one direction of dot motion from the rest of the display filled with another direction of dot motion
Memory processing
Letter memoryAssesses memory using specialized sets of visual stimuli
Measures the subject’s ability to recall which letter was presented as a pre-cue, and then select that letter from a display of alternative items, despite the addition of increasing amounts of clutter
Select the correct letter of the English alphabet
Word memoryAs above
Select the correct 3-letter word
Shape memoryAs above
Select the correct shape
Motion memoryAs above
Select the correct direction of motion
Table 2 Summary of the purpose and analyses of the components of the Food and Drug Administration pivotal clinical trial of Cognivue®
Validation of classification scoresPurpose: Assess the validity of the previously defined Cognivue® cut-off scores in a larger sample of subjects
Methods: Scores on Cognivue® and SLUMS were compared using regression and classification analyses. PPA and NPA were calculated
Assessment of retest reliabilityPurpose: Compare scores from repeated administration of Cognivue® to assess retest reliability, compare findings to parallel results from SLUMS
Methods: Repeated Cognivue® and SLUMS testing was conducted in 2 sessions 1-2 wk apart with regression and rank linear regression analysis being performed
Assessment of score psychometrics vs other neuropsychological testsPurpose: Compare scores on Cognivue® and other neuropsychological tests to describe relationship and compare them to SLUMS
Methods: 401 participants completed 10 different tests [SLUMS, SLUMS-clock drawing1, SLUMS-animal naming1, RAVLT, TMT-A, TMT-B, Benton JOLO, figural memory, PPB, HVCS, GDS (15-item)]; rank linear regression analysis and factor analysis performed
Table 3 Summary of Cognivue® cut-off score analysis
SLUMS cut-off scoresCognivue® cut-off scores
Impaired< 21≤ 50
Mildly impaired (intermediate)21-2651-74
Unimpaired> 26≥ 75
Table 4 Proportion of participants classified in each impairment category by first and second Cognivue® tests
2nd Test1st Test
Impaired42 (89%)21063
Intermediate541 (57%)3278
Unimpaired010207 (87%)217
Table 5 Factor analysis component matrix for the neuropsychological test scores indicating correlations with Cognivue®
SLUMS-clock drawing0.4200.3380.0380.367-0.049
SLUMS-animal naming0.52910.3460.1460.365-0.125
Peg Board-Left0.2470.79620.2970.120-0.090
Peg Board-Right0.2970.75220.2060.160-0.186
Peg Board-Bimanual0.2930.82220.2300.134-0.137
Benton JOLO0.1850.196-0.0240.4994-0.344
Figural memory0.2720.2430.2020.3760.047