Published online Nov 9, 2018. doi: 10.5498/wjp.v8.i5.114
Peer-review started: July 10, 2018
First decision: August 24, 2018
Revised: October 7, 2018
Accepted: October 23, 2018
Article in press: October 23, 2018
Published online: November 9, 2018
Core tip: A collaborative treatment alliance is central to tackling the ubiquitous problem of non-adherence in bipolar disorder (BD). Studies examining the link between alliance and adherence in BD have shown that an effective alliance positively impacts adherence. However, the existing literature is relatively limited, often of variable quality, and has not been able to clearly delineate the mediators of the alliance-adherence connection. Nevertheless, the key elements of productive alliances in BD which could positively influence treatment-adherence are reasonably clear. They can be readily implemented in clinical practice to enhance adherence in BD, till future research further clarifies the alliance-adherence association.