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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatr. Mar 22, 2016; 6(1): 31-42
Published online Mar 22, 2016. doi: 10.5498/wjp.v6.i1.31
Published online Mar 22, 2016. doi: 10.5498/wjp.v6.i1.31
Role of astrocytic glutamate transporter in alcohol use disorder
Jennifer R Ayers-Ringler, Neurobiology of Disease PhD Program, Mayo Graduate School, Mayo Clinic, Rochester, MN 55905, United States
Yun-Fang Jia, Yan-Yan Qiu, Doo-Sup Choi, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, MN 55905, United States
Author contributions: All authors contributed equally to conception and design of the manuscript, analysis and interpretation of data, drafting, and making critical revisions of the manuscript; all authors gave final approval of the version of the article to be published.
Supported by Mayo Graduate School, NIAAA, No. AA018779; SC Johnson Genomics of Addiction Program, Ulm Family Foundation, Center for Individualized Medicine at Mayo; and David Lehr Research Award from American Society for Pharmacology and Experimental Therapeutics.
Conflict-of-interest statement: No potential conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Doo-Sup Choi, PhD, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, United States. choids@mayo.edu
Telephone: +1-507-2845602 Fax: +1-507-2841767
Received: August 29, 2015
Peer-review started: September 6, 2015
First decision: November 11, 2015
Revised: December 18, 2015
Accepted: January 8, 2016
Article in press: January 11, 2016
Published online: March 22, 2016
Peer-review started: September 6, 2015
First decision: November 11, 2015
Revised: December 18, 2015
Accepted: January 8, 2016
Article in press: January 11, 2016
Published online: March 22, 2016
Core Tip
Core tip: Review of astroglial involvement in alcohol use disorder and potential for astrocyte-specific glutamate transporter excitatory amino acid transporter type 2 (EAAT2, Slc1a2)/GLT-1 in pharmacological treatment, including alcohol withdrawal symptoms.