Good KP, Sullivan RL. Olfactory function in psychotic disorders: Insights from neuroimaging studies. World J Psychiatr 2015; 5(2): 210-221 [PMID: 26110122 DOI: 10.5498/wjp.v5.i2.210]
Corresponding Author of This Article
Kimberley P Good, PhD, Departments of Psychiatry and Psychology and Neuroscience, Dalhousie University, Suite 4064 AJLB, 5909 Veterans Memorial Lane, Halifax NS B3H2E2, Canada. kim.good@dal.ca
Research Domain of This Article
Neuroimaging
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Psychiatr. Jun 22, 2015; 5(2): 210-221 Published online Jun 22, 2015. doi: 10.5498/wjp.v5.i2.210
Olfactory function in psychotic disorders: Insights from neuroimaging studies
Kimberley P Good, Randii Lynn Sullivan
Kimberley P Good, Departments of Psychiatry and Psychology and Neuroscience, Dalhousie University, Halifax NS B3H2E2, Canada
Randii Lynn Sullivan, Department of Social Work, Dalhousie University, Halifax NS B3H2E2, Canada
Author contributions: Both authors contributed to this manuscript.
Supported by In part the Department of Psychiatry Dalhousie University; The Faculty of Medicine at Dalhousie University; The Nova Scotia Health Research Fund; and the Canadian Institutes of Health Research.
Conflict-of-interest: The authors know of no conflicts of interest related to this work.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Kimberley P Good, PhD, Departments of Psychiatry and Psychology and Neuroscience, Dalhousie University, Suite 4064 AJLB, 5909 Veterans Memorial Lane, Halifax NS B3H2E2, Canada. kim.good@dal.ca
Telephone: +1-902-4734250 Fax: +1-902-4733456
Received: December 2, 2014 Peer-review started: December 4, 2014 First decision: January 20, 2015 Revised: February 20, 2015 Accepted: March 16, 2015 Article in press: March 18, 2015 Published online: June 22, 2015
Core Tip
Core tip: Olfactory identification, familiarity, and memory deficits are consistently noted in patients with psychotic disorders relative to age-matched controls. Olfactory intensity ratings remain intact while olfactory hedonics and detection threshold show inconsistent findings. This review found no consistent differences in functional activity in amygdala and pirifom cortices in psychotic patients relative to control subjects. Secondary olfactory cortices were abnormally activated in psychosis patients, however. Further methodologically consistent research is required for better understanding the neurobiology of olfactory deficits in psychotic disorders. The authors recommend examining sex differences contrasting olfactory subgroups (impaired vs intact) in future examinations.
