Review
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatr. Mar 22, 2015; 5(1): 35-46
Published online Mar 22, 2015. doi: 10.5498/wjp.v5.i1.35
Smoking in schizophrenic patients: A critique of the self-medication hypothesis
Francesca Manzella, Susan E Maloney, George T Taylor
Francesca Manzella, George T Taylor, Behavioral Neuroscience Program, Department of Psychological Sciences, University of Missouri-St. Louis, St. Louis, MO 63121, United States
Susan E Maloney, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, United States
Susan E Maloney, Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, United States
Author contributions: Manzella F, Maloney SE and Taylor GT solely contributed to this paper.
Supported by In part by grants from the University of Missouri System, including the UM-Research Board and the Interdisciplinary Intercampus Research Program to GTT and from the W.M. Keck Foundation to SEM.
Conflict-of-interest: The authors of this manuscript have no conflicts of interest to report.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Susan E Maloney, PhD, Department of Genetics, Washington University School of Medicine, 4655 Scott Ave, Campus Box 8232, St. Louis, MO 63110, United States. maloneys@psychiatry.wustl.edu
Telephone: +1-314-5165397 Fax: +1-314-5165397
Received: September 29, 2014
Peer-review started: September 29, 2014
First decision: October 28, 2014
Revised: November 27, 2014
Accepted: January 9, 2015
Article in press: January 12, 2015
Published online: March 22, 2015
Core Tip

Core tip: The high rates of smoking in mentally ill people have led to the uncritical acceptance that these individuals smoke to self-medicate with nicotine. A self-medication hypothesis (SMH) proposed three decades ago set the stage for explanations for smoking associated with mental illness. Here, we review the origins of the SMH and apply stated and implied predictions to smoking in patients. Our conclusions are that there is some support for the SMH explanations for smoking in schizophrenic patients. However, there are sufficient contradictory data, and predictions not adequately tested, to justify continued empirical studies and new alternative hypotheses to the self-medication concept.