Published online Jun 22, 2013. doi: 10.5498/wjp.v3.i2.8
Revised: February 25, 2013
Accepted: March 15, 2013
Published online: June 22, 2013
Core tip: A profound disturbance of emotional experiences is one of the key symptoms of major depressive disorder. Therefore, we investigated alterations in neural correlates of emotional experiences in individuals at risk for major depression to identify potential vulnerability markers for depression. Pleasant and unpleasant emotional states were induced via music and emotional faces while recording brain responses via functional magnetic resonance imaging. Our study shows that pregenual anterior cingulate cortex reactivity in response to emotional stimuli can serve as a “neural marker” for depression vulnerability - a finding that, if replicated, could be important for innovations in early diagnosis or therapy.