Bhave S, Darji Y, Prajapati A. Neuropsychiatric manifestations of prostate cancer and its treatment: Biological mechanisms and psycho-oncology perspectives. World J Psychiatry 2026; 16(11): 125256 [DOI: 10.5498/wjp.125256]
Corresponding Author of This Article
Akhilesh Prajapati, PhD, Associate Professor, Research Dean, Division of Biotechnology, School of Life Sciences, GSFC University, Vigyan Bhawan, Fertilizer Nagar, Vadodara 391750, Gujarāt, India. akhileshbiotech06@gmail.com
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Psychiatry
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review-article
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Bhave S, Darji Y, Prajapati A. Neuropsychiatric manifestations of prostate cancer and its treatment: Biological mechanisms and psycho-oncology perspectives. World J Psychiatry 2026; 16(11): 125256 [DOI: 10.5498/wjp.125256]
World J Psychiatry. Nov 19, 2026; 16(11): 125256 Published online Nov 19, 2026. doi: 10.5498/wjp.125256
Neuropsychiatric manifestations of prostate cancer and its treatment: Biological mechanisms and psycho-oncology perspectives
Shivani Bhave, Yash Darji, Akhilesh Prajapati
Shivani Bhave, Yash Darji, Akhilesh Prajapati, Division of Biotechnology, School of Life Sciences, GSFC University, Vadodara 391750, Gujarāt, India
Author contributions: Prajapati A conceptualized the idea for the review, prepared the study summaries, supervised the overall work and critically revised the manuscript; Bhave S, Darji Y and Prajapati A jointly contributed to the design, discussion and writing of the review manuscript.
AI contribution statement: No AI tools were used during the manuscript preparation process.
Supported by GSBTM, DST Government of Gujarat, No. GSBTM/RSS/E-FILE/30/2024/0021/04306791.
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
Corresponding author: Akhilesh Prajapati, PhD, Associate Professor, Research Dean, Division of Biotechnology, School of Life Sciences, GSFC University, Vigyan Bhawan, Fertilizer Nagar, Vadodara 391750, Gujarāt, India. akhileshbiotech06@gmail.com
Received: July 2, 2026 Revised: August 13, 2026 Accepted: October 8, 2026 Published online: November 19, 2026 Processing time: 119 Days and 18.1 Hours
Core Tip
Core Tip: Prostate cancer and its treatment can produce substantial neuropsychiatric consequences that extend beyond conventional physical and oncological outcomes. The available evidence supports routine recognition of psychological distress and targeted evaluation of mood and cognitive symptoms in higher-risk patients. Mechanistic biomarkers, neuroimaging approaches and precision psycho-oncology strategies remain important areas for further prospective validation. This narrative review distinguishes direct prostate cancer evidence from indirect mechanistic context and emphasizes practical psycho-oncology assessment alongside research priorities in neuroimaging, biomarkers and longitudinal care. We further highlight neuroimaging approaches, global disparities in psycho-oncological care and emerging brain–tumor communication pathways.
