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World J Psychiatry. Nov 19, 2026; 16(11): 125243
Published online Nov 19, 2026. doi: 10.5498/wjp.125243
Published online Nov 19, 2026. doi: 10.5498/wjp.125243
Inflammation, sleep-circadian disruption, and neuropsychiatric recovery after stroke: Mechanisms and integrated interventions for post-stroke depression and anxiety
Xing-An Liu, Jun Liu, Department III of Neurology Rehabilitation, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110000, Liaoning Province, China
Dan Xu, Department of Psychiatry, Shenyang Mental Health Center, Shenyang 110062, Liaoning Province, China
Xia Zhao, Department Five of Neurology Rehabilitation, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110000, Liaoning Province, China
Author contributions: Liu XA contributed to the conception and design of the study, data curation, methodology, software development, and drafted the original manuscript; Liu J and Xu D carried out formal analysis, project administration and visualization; Zhao X conducted investigation, supervision and validation, and revised the manuscript; and all authors read and approved the final submitted manuscript.
AI contribution statement: Only the content in the “Answering-Reviewers” file is suitable for being polished by AI.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Xia Zhao, Director, Department Five of Neurology Rehabilitation, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, No. 33 Beiling Street, Shenyang 110000, Liaoning Province, China. zhaoxia57157@126.com
Received: July 3, 2026
Revised: July 22, 2026
Accepted: August 10, 2026
Published online: November 19, 2026
Processing time: 118 Days and 0.2 Hours
Revised: July 22, 2026
Accepted: August 10, 2026
Published online: November 19, 2026
Processing time: 118 Days and 0.2 Hours
Core Tip
Core Tip: This article synthesizes evidence on the clinical interplay between post-stroke depression/anxiety, sleep disturbance, and circadian dysregulation, highlighting shared inflammatory mechanisms. It proposes a comprehensive framework integrating mood monitoring, sleep-circadian evaluation, biomarker assessment, and phenotype-based interventions to address these interconnected contributors to poor functional recovery and rehabilitation outcomes.