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World J Psychiatry. Nov 19, 2026; 16(11): 124191
Published online Nov 19, 2026. doi: 10.5498/wjp.124191
Published online Nov 19, 2026. doi: 10.5498/wjp.124191
Stepwise psychological intervention: Mitigated psychological distress and suicide risk in patients with liver cancer chemoembolization
Hui-Xi Yu, Wei-Wei Zhao, Yin-Ying Wang, Department of Vascularsurgery/Interventional Medicine, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China
Chao-Ling Huang, Chun-Jing Zhu, Yi-Man Jin, Department of Gastroenterology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China
Author contributions: Yu HX designed the research, collected and analyzed the relevant data, and drafted the original manuscript; Huang CL, Zhu CJ, Zhao WW and Wang YY participated in case screening, data sorting and result validation; Jin YM as the corresponding author, supervised the whole study, provided important academic guidance, critically revised the manuscript, and confirmed the final version for submission; all authors have read and approved the final manuscript.
AI contribution statement: The authors declare that no AI tools were used in the development or writing of this manuscript and take full responsibility for its integrity, accuracy, and originality.
Institutional review board statement: This study has been reviewed and approved by the Medical Ethics Committee of The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University (approval No. 2024-K-048-02).
Informed consent statement: All the individuals who participated in this study provided their written informed consent prior to study enrolment.
Conflict-of-interest statement: The authors declare no conflicts of interest.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Data sharing statement: No additional data are available.
Corresponding author: Yi-Man Jin, Chief Physician, Department of Gastroenterology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, No. 109 Xueyuan West Road, Lucheng District, Wenzhou 325000, Zhejiang Province, China. jym-715@163.com
Received: July 14, 2026
Revised: August 17, 2026
Accepted: October 8, 2026
Published online: November 19, 2026
Processing time: 106 Days and 15.4 Hours
Revised: August 17, 2026
Accepted: October 8, 2026
Published online: November 19, 2026
Processing time: 106 Days and 15.4 Hours
Core Tip
Core Tip: This study adopted a stepwise psychological intervention for patients with liver cancer receiving trans arterial chemoembolization plus targeted therapy. This tiered intervention relieves psychological distress and suicide risk, improves treatment compliance, and reduces the incidence of ward safety events. Poor mood and advanced tumor stage are high-risk factors.