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World J Psychiatry. Nov 19, 2026; 16(11): 123531
Published online Nov 19, 2026. doi: 10.5498/wjp.123531
Published online Nov 19, 2026. doi: 10.5498/wjp.123531
Neural correlates of aggressive impulsive behavior differ between schizophrenia and bipolar disorder: An event-related potential study with a go/no-go task
Xin-Ping Li, Jia-Xv Li, Zhen-He Zhou, Department of Psychiatry, The Affiliated Mental Health Center of Jiangnan University, Training Base of Hubei University of Medicine, Shiyan 442000, Hubei Province, China
Xin-Ping Li, Jing Zhang, Qi Liu, Yu-Qing Wu, Wen-Yu Yang, Xiao-Hong Liu, Yi-Fan Sun, Hong-Liang Zhou, Zhen-He Zhou, Zhan-Zhan Dai, Xin-Yu Wang, Department of Psychiatry, The Affiliated Mental Health Center of Jiangnan University, Wuxi 214151, Jiangsu Province, China
Hong-Liang Zhou, Department of Psychology, The Affiliated Hospital of Jiangnan University, Wuxi 214151, Jiangsu Province, China
Co-first authors: Xin-Ping Li and Jing Zhang.
Co-corresponding authors: Zhan-Zhan Dai and Xin-Yu Wang.
Author contributions: Dai ZZ and Wang XY designed the study and contributed equally as co-corresponding authors; Li XP, Zhang J, Liu Q, Wu YQ, Yang WY, Li JX, Liu XH, and Sun YF recruited participants and collected the data; Li XP and Zhang J contributed equally as co-first authors; Li XP, Zhang J, Zhou ZH, and Zhou HL analyzed data and drafted the manuscript. All authors contributed to the interpretation of the results, manuscript revision, and approved the final version of the manuscript.
AI contribution statement: Portions of this manuscript were edited using AI tools (DeepSeek) solely for language refinement. The authors carefully reviewed and verified all AI-assisted outputs and take full responsibility for the scientific content of the manuscript.
Supported by Wuxi Taihu Talent Project, No. WXTTP 2021.
Institutional review board statement: This study was approved by the Ethics Committee of Wuxi Mental Health Center (approval No. WXMHCIRB2025 LLky014).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: Data used in this study can be available from the corresponding author upon request.
Corresponding author: Xin-Yu Wang, Department of Psychiatry, The Affiliated Mental Health Center of Jiangnan University, No. 156 Qianrong Road, Wuxi 214151, Jiangsu Province, China. wxycc0321@sina.com
Received: May 21, 2026
Revised: June 22, 2026
Accepted: July 20, 2026
Published online: November 19, 2026
Processing time: 161 Days and 22.8 Hours
Revised: June 22, 2026
Accepted: July 20, 2026
Published online: November 19, 2026
Processing time: 161 Days and 22.8 Hours
Core Tip
Core Tip: This study utilized the emotional go/no-go task to examine behavioral performance, event-related potential characteristics, and aggressive impulse scale data, aiming to reveal the possible differences in the neural mechanisms of aggressive behavior in patients with schizophrenia (SCZ) and bipolar disorder (BD), and to further deepen the research on the cognitive function of patients with SCZ and BD, to provide new therapeutic targets and targeted interventions for aggressive behavior in patients with SCZ and BD.