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World J Psychiatry. Nov 19, 2026; 16(11): 123323
Published online Nov 19, 2026. doi: 10.5498/wjp.123323
Published online Nov 19, 2026. doi: 10.5498/wjp.123323
Impact of multicomponent, nonpharmacological care program for mild Alzheimer’s disease with anxiety and depression
Ya-Fei Chen, Yan Zhu, Department of General Medicine, Shaoxing 7th People’s Hospital, Shaoxing 312000, Zhejiang Province, China
Bi-Xia Li, Jin-Na Zhang, Department of Psychiatry VI, Shaoxing 7th People’s Hospital, Shaoxing 312000, Zhejiang Province, China
Author contributions: Chen YF initiated research; Zhu Y, Li BX, and Zhang JN designed the experiments and conducted clinical data collection, performed postoperative follow-up and recorded the data; Chen YF conducted the collation and statistical analysis, and wrote the original manuscript and revised the paper; all authors read and approved the final manuscript.
AI contribution statement: No AI tools were used in writing, editing, or generating any part of this manuscript, including text, images, and data analysis.
Supported by Zhejiang Province Health Industry Science and Technology Plan Project, No. 2025HY1317.
Institutional review board statement: This study was approved by the Ethics Committee of Shaoxing 7th People’s Hospital (No. 2025-039-01).
Informed consent statement: The ethics committee agrees to waive informed consent.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: All data generated or analyzed during this study are included in this published article.
Corresponding author: Ya-Fei Chen, MD, Doctor, Department of General Medicine, Shaoxing 7th People’s Hospital, No. 1234 Shengli West Road, Yuecheng District, Shaoxing 312000, Zhejiang Province, China. chenyfly258@163.com
Received: May 15, 2026
Revised: June 22, 2026
Accepted: July 13, 2026
Published online: November 19, 2026
Processing time: 166 Days and 22.6 Hours
Revised: June 22, 2026
Accepted: July 13, 2026
Published online: November 19, 2026
Processing time: 166 Days and 22.6 Hours
Core Tip
Core Tip: This study evaluates a multicomponent nonpharmacological care program (cognitive rehabilitation, occupational therapy, art/doll therapy, exercise training, and speech therapy) in mild Alzheimer’s disease patients with comorbid anxiety and depression. Compared to conventional care, the program significantly improved neuropsychiatric symptoms, quality of life, caregiver burden, cognitive function, and sleep quality. The findings support a holistic, nondrug approach for this specific population.