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World J Psychiatry. Nov 19, 2026; 16(11): 122665
Published online Nov 19, 2026. doi: 10.5498/wjp.122665
Published online Nov 19, 2026. doi: 10.5498/wjp.122665
Anxiety-depression after intravascular ultrasound-guided drug-coated balloon angioplasty dissection: Predictors and 12-month cardiovascular outcomes
Jia-Xi Pan, Yong-Guang Wang, Jun-Jie Wang, Yun-Rui Zhang, Department of Cardiology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou 325200, Zhejiang Province, China
Li-Ping Xu, General Ward, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou 325200, Zhejiang Province, China
Jia-Ling Qiu, Department of Hematology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou 325200, Zhejiang Province, China
Author contributions: Pan JX and Zhang YR contributed to conceptualization; Pan JX and Xu LP contributed to data curation; Pan JX contributed to formal analysis, methodology, and writing - original draft; Pan JX, Xu LP, Qiu JL, Wang YG, Wang JJ, and Zhang YR contributed to writing - review and editing; Xu LP, Qiu JL, and Wang YG contributed to investigation; Xu LP contributed to patient follow-up coordination; Qiu JL contributed to laboratory data collection and management; Wang YG contributed to procedural data collection; Wang JJ contributed to resources and validation; Zhang YR contributed to funding acquisition, project administration, and supervision. All authors have read and approved the final version of the manuscript.
AI contribution statement: The authors declare that no AI tools were used in the preparation of this manuscript, including study design, data collection, data analysis, interpretation of results, manuscript writing, or language editing. The authors assume full responsibility for the integrity, accuracy and originality of the manuscript and all submitted materials.
Supported by Medical and Health Science Program of Zhejiang Province, No. 2025HY1120; Joint TCM Science and Technology Projects of National Demonstration Zones for Comprehensive TCM Reform, No. 2026ZL0825; Medical and Health Research Program of Wenzhou City, No. 2024050; and Ruian Municipal Science and Technology Plan Project, No. MS2024062.
Institutional review board statement: The study was reviewed and approved by the Ethics Committee of The Third Affiliated Hospital of Wenzhou Medical University (approval No. YJ2025145; approved on November 6, 2025). All data extraction and analysis were performed after ethics approval had been granted.
Informed consent statement: The requirement for written informed consent was waived by the Ethics Committee of The Third Affiliated Hospital of Wenzhou Medical University owing to the retrospective design of the study and the use of anonymized medical records.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: The datasets generated and/or analyzed during the current study are available from the corresponding author
Corresponding author: Yun-Rui Zhang, MD, Department of Cardiology, The Third Affiliated Hospital of Wenzhou Medical University, No. 108 Wansong Road, Wenzhou 325200, Zhejiang Province, China. bruceyun24@163.com
Received: May 22, 2026
Revised: July 28, 2026
Accepted: September 21, 2026
Published online: November 19, 2026
Processing time: 159 Days and 22.4 Hours
Revised: July 28, 2026
Accepted: September 21, 2026
Published online: November 19, 2026
Processing time: 159 Days and 22.4 Hours
Core Tip
Core Tip: Clinically significant anxiety-depression developed in 38.7% of patients following coronary dissection after intravascular ultrasound-guided drug-coated balloon angioplasty, and was independently associated with a nearly threefold higher 12-month major adverse cardiovascular event rate. Seven independent predictors were identified, and a composite model achieved an area under the curve of 0.86, supporting routine psychocardiological screening in this population.