Randomized Clinical Trial
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Sep 19, 2025; 15(9): 109478
Published online Sep 19, 2025. doi: 10.5498/wjp.v15.i9.109478
Community-based assisted screening for mild cognitive impairment using gait and handwriting kinematic parameters analysis
Yin-Xia Ren, Bei Wu, Jian-Lin Lou, Xiao-Rong Zhu, Chen Zhang, Qing Lang, Zhu-Qin Wei, Li-Ming Su, Heng-Nian Qi, Li-Na Wang
Yin-Xia Ren, Li-Na Wang, School of Medicine, Huzhou Key Laboratory of Precise Prevention and Control of Major Chronic Diseases, Huzhou University, Huzhou 313000, Zhejiang Province, China
Bei Wu, Rory Meyers College of Nursing, New York University, New York, NY 10010, United States
Jian-Lin Lou, School of Medicine, Huzhou Key Laboratory of Precise Prevention and Control of Major Chronic Diseases, The First Affiliated Hospital, Huzhou University, Huzhou 313000, Zhejiang Province, China
Xiao-Rong Zhu, Heng-Nian Qi, Department of Information Engineering, Huzhou University, Huzhou 313000, Zhejiang Province, China
Chen Zhang, Renhuangshan Binhu Community Health Service Centre, Renhuangshan Binhu Community Health Service Centre, Huzhou 313000, Zhejiang Province, China
Qing Lang, Library, Huzhou University, Huzhou 313000, Zhejiang Province, China
Zhu-Qin Wei, Department of Nursing, Shanghai General Hospital, Shanghai 201600, China
Li-Ming Su, School of Medicine, Zhejiang Ocean University, Zhoushan 316022, Zhejiang Province, China
Co-corresponding authors: Heng-Nian Qi and Li-Na Wang.
Author contributions: Ren YX and Wang LN contributed to the study conception and design; Ren YX, Zhu XR, Wei ZQ and Wang LN conducted the acquisition, curation and analysis of data; Zhang C, Lang Q, Qi HN and Lou JL supervised the research; Wu B, Zhu XR, Wei ZQ, and Su LM provided methodological input on data analysis; Ren YX and Wang LN drafted the manuscript; Wu B, Lou JL and Qi HN revised the manuscript critically for important intellectual content. All authors have read and approve the final manuscript. We have designated Wang LN and Qi HN as co-corresponding authors due to their significant and complementary contributions to this study. Wang LN was deeply involved in the conception, design, data acquisition, and manuscript drafting, playing a key role in the study's foundation and execution. Qi HN supervised the overall research process and critically revised the manuscript for intellectual content, ensuring its academic rigor and integrity. Their combined efforts ensured both the methodological soundness and the strategic direction of the project. Given their respective responsibilities and leadership roles throughout different stages of the study, assigning them as co-corresponding authors accurately reflects their contributions and ensures effective communication with the journal and academic community.
Supported by National Natural Science Foundation of China, No. 72174061 and No. 71704053; Key Research and Development Program of Zhejiang Province, No. 2025C02106; China Scholarship Council Foundation, No. 202308330251; and Health Science and Technology Project of Zhejiang Provincial Health Commission, No. 2022KY370.
Institutional review board statement: The study was reviewed and approved by the Third People’s Hospital Institutional Review Board [(Approval No. 2024-474)].
Clinical trial registration statement: This study is registered at https://www.chictr.org.cn/. The registration identification number is ChiCTR2400089057.
Informed consent statement: All study participants provided informed written consent prior to study enrollment.
Conflict-of-interest statement: None of the authors declare any conflicts of interest.
CONSORT 2010 statement: The authors have read the CONSORT 2010 statement, and the manuscript was prepared and revised according to the CONSORT 2010 statement.
Data sharing statement: The datasets generated or analyzed during the current study are not publicly available but will be available from the corresponding author upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Li-Na Wang, PhD, Professor, School of Medicine, Huzhou Key Laboratory of Precise Prevention and Control of Major Chronic Diseases, Huzhou University, No. 759 Erhuan East Road, Huzhou 313000, Zhejiang Province, China. 02474@zjhu.edu.cn
Received: May 13, 2025
Revised: June 9, 2025
Accepted: July 8, 2025
Published online: September 19, 2025
Processing time: 106 Days and 1.1 Hours
Core Tip

Core Tip: This study introduces sensitive biomarkers for assisted screening of mild cognitive impairment (MCI) by integrating gait and handwriting kinematic parameters. The findings demonstrate that the combination of gait analysis and handwriting tasks achieves a detection accuracy of 74.44% for MCI, outperforming single-task assessments. These parameters could complement traditional tool like the Montreal cognitive assessment by reducing reliance on subjective assessments and minimizing cultural, language, and educational biases. This research establishes a foundation for translating these precision biomarkers into cost-effective, portable, and scalable wearable technologies, which could enable large-scale, rapid screening of high-risk individuals with MCI in community settings.