Zhou XL, Li Y, Xia W, Zheng YY, Wu AP. Advances in transcranial magnetic stimulation for psychological symptom management in Parkinson’s disease. World J Psychiatry 2025; 15(9): 108497 [DOI: 10.5498/wjp.v15.i9.108497]
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Psychiatry. Sep 19, 2025; 15(9): 108497 Published online Sep 19, 2025. doi: 10.5498/wjp.v15.i9.108497
Advances in transcranial magnetic stimulation for psychological symptom management in Parkinson’s disease
Xiao-Li Zhou, Yan Li, Wan Xia, Ying-Ying Zheng, Ai-Ping Wu
Xiao-Li Zhou, Wan Xia, Ying-Ying Zheng, Ai-Ping Wu, Department of Rehabilitation, Zhejiang Hospital, Hangzhou 310012, Zhejiang Province, China
Yan Li, Department of Neurology, Zhejiang Hospital, Hangzhou 310012, Zhejiang Province, China
Author contributions: Zhou XL conducted literature review and initial drafting; Li Y provided neurological expertise and clinical experience; Xia W handled literature screening and data organization; Zheng YY focused on transcranial magnetic stimulation applications and manuscript revision, and corresponding author Wu AP oversaw research design, overall coordination, and final review.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Received: May 16, 2025 Revised: June 16, 2025 Accepted: July 18, 2025 Published online: September 19, 2025 Processing time: 102 Days and 1.4 Hours
Core Tip
Core Tip: This review summarizes recent advances in transcranial magnetic stimulation (TMS) for managing psychological symptoms in Parkinson’s disease, including depression, anxiety, cognitive impairment, impulse control disorders, and sleep disturbances. It highlights the neurophysiological mechanisms of TMS, such as modulation of the prefrontal-striatal dopamine pathway and promotion of neuroplasticity. Clinical applications of repetitive TMS and theta burst stimulation are discussed, along with individualized parameter optimization strategies. The article also outlines future directions involving deep TMS, neuronavigation, and personalized protocols, offering novel insights into non-invasive neuromodulation for comprehensive symptom management in Parkinson’s disease.
