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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Sep 19, 2025; 15(9): 107498
Published online Sep 19, 2025. doi: 10.5498/wjp.v15.i9.107498
Published online Sep 19, 2025. doi: 10.5498/wjp.v15.i9.107498
Role of RNA-binding proteins in exercise-induced mRNA regulation: Unveiling biomarkers and therapeutic targets for schizophrenia
Yao Lu, Jian-Da Kong, Lu-Nan Zhao, College of Sports Science, Qufu Normal University, Jining 273100, Shandong Province, China
Co-corresponding authors: Jian-Da Kong and Lu-Nan Zhao.
Author contributions: Lu Y wrote the main text; Zhao LN provided proofreading and funding support; Kong JD was responsible for topic design, final proofreading, and the decision on the final version; Kong JD and Zhao LN they contributed equally to this article, they are the co-corresponding authors of this manuscript; and all authors thoroughly reviewed and endorsed the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jian-Da Kong, PhD, College of Sports Science, Qufu Normal University, No. 56 Jingxuan West Road, Jining 273100, Shandong Province, China. jianda0426@163.com
Received: March 27, 2025
Revised: June 5, 2025
Accepted: July 8, 2025
Published online: September 19, 2025
Processing time: 153 Days and 20.9 Hours
Revised: June 5, 2025
Accepted: July 8, 2025
Published online: September 19, 2025
Processing time: 153 Days and 20.9 Hours
Core Tip
Core Tip: This review highlights recent insights into RNA-binding proteins (RBPs) and their regulatory roles in exercise-induced mRNA expression, with a special focus on schizophrenia (SZ). RBPs control mRNA stability, translation, and localization, which are critical for neural function and synaptic plasticity. Exercise modulates the expression and function of specific RBPs, potentially improving neurotransmission and neural health. Abnormal RBP expression is linked to SZ pathophysiology, and certain RBPs may serve as biomarkers or therapeutic targets. Our findings suggest that exercise may be a promising adjunctive intervention to regulate RBPs and mitigate SZ symptoms.