Medication literacy and treatment adherence in people living with human immunodeficiency virus: Mediating effects of psychosocial factors

doi:10.5498/wjp.v15.i8.107885

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Aug 19, 2025 (publication date) through Aug 8, 2025

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Psychiatry. Aug 19, 2025; 15(8): 107885
Published online Aug 19, 2025. doi: 10.5498/wjp.v15.i8.107885

Medication literacy and treatment adherence in people living with human immunodeficiency virus: Mediating effects of psychosocial factors

Cheng-Hua Xu, Di Hu, Hui-Jiao Lin, Yi-De Yang, Meng-Nan Li, Le-Wen Shao

Cheng-Hua Xu, Le-Wen Shao, Department of Nursing, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310006, Zhejiang Province, China

Cheng-Hua Xu, Department of Hepatobiliary Surgery, Taizhou Municipal Hospital, Taizhou 318000, Zhejiang Province, China

Di Hu, Department of Hospital Infection Management Section, Taizhou Municipal Hospital, Taizhou 318000, Zhejiang Province, China

Hui-Jiao Lin, Department of Emergency Medicine, Taizhou Municipal Hospital, Taizhou 318000, Zhejiang Province, China

Yi-De Yang, Department of Infectious Diseases, Taizhou Municipal Hospital, Taizhou 318000, Zhejiang Province, China

Meng-Nan Li, Department of Nursing, Taizhou Municipal Hospital, Taizhou 318000, Zhejiang Province, China

Author contributions: Xu CH and Hu D conceptualized and designed the study; Lin HJ and Yang YD conducted the literature review, collected and analyzed relevant references, and contributed to the initial drafting of the manuscript; Li MN designed and prepared the tables; Shao LW reviewed and revised the manuscript for intellectual content and finalized the manuscript for submission. All authors have read and approved the final version of the manuscript.

Supported by Taizhou Municipal Hospital, No. 2025JK317 and No. 2025JK318.

Conflict-of-interest statement: The authors declare no conflicts of interest related to this manuscript.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Le-Wen Shao, MD, Deputy Director, Department of Nursing, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 1367 Wenyi West Road, Yuhang District, Hangzhou 310006, Zhejiang Province, China. 951109@zju.edu.cn

Received: March 30, 2025
Revised: May 17, 2025
Accepted: June 12, 2025
Published online: August 19, 2025
Processing time: 130 Days and 19.5 Hours

Core Tip

Core Tip: This review highlights how medication literacy influences treatment adherence among people living with human immunodeficiency virus (HIV) through key psychosocial mediators such as stigma, self-efficacy, and social support. It integrates neurobehavioral insights and sociocultural factors, offering a multidimensional framework for understanding and improving adherence. The findings support tailored psychosocial interventions-like cognitive behavioral therapy and culturally adapted education-to enhance patient outcomes and inform holistic HIV care strategies.