Review
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World J Psychiatry. Aug 19, 2025; 15(8): 107791
Published online Aug 19, 2025. doi: 10.5498/wjp.v15.i8.107791
Startle response and its prepulse modification in health and under different psychopathologies: Could we find any specific patterns?
Zinaida I Storozheva
Zinaida I Storozheva, Laboratory of Neurophysiology and Neurochemistry, Department of Neuropsychopharmacology, Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, Moscow 125315, Russia
Author contributions: Storozheva ZI designed the review framework, identified the research focus, conducted the literature search and analysis of the data, drafted the manuscript, provided critical revisions and final approval of the manuscript.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zinaida I Storozheva, Senior Scientist, Laboratory of Neurophysiology and Neurochemistry, Department of Neuropsychopharmacology, Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, Baltiiskaya, 8, Moscow 125315, Russia. storozheva_zi@mail.ru
Received: April 2, 2025
Revised: May 2, 2025
Accepted: July 3, 2025
Published online: August 19, 2025
Processing time: 132 Days and 0.3 Hours
Core Tip

Core Tip: There are several reviews in the literature dedicated to phenomenon of prepulse modification of the startle response. In these manuscripts its deficiency in neuropsychiatric disorders regarded as transdiagnostic process. Here we review the evidence in favor of the specificity of certain prepulse modification changes for certain pathologies of pathology and consider the prospects for future research on this issue.