Copyright
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Jul 19, 2025; 15(7): 106062
Published online Jul 19, 2025. doi: 10.5498/wjp.v15.i7.106062
Published online Jul 19, 2025. doi: 10.5498/wjp.v15.i7.106062
Gut-skin-brain axis in people suffering from sepsis with acute skin failure
Takahiko Nagamine, Psychiatric Internal Medicine, Sunlight Brain Research Center, Hofu 7470066, Yamaguchi, Japan
Author contributions: Nagamine T contributed to the conceptualization, methodology, formal analysis and investigation, writing of the original manuscript, review and editing, and supervision of the manuscript.
Conflict-of-interest statement: The author has no conflicts of interest to declare.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Takahiko Nagamine, MD, PhD, Psychiatric Internal Medicine, Sunlight Brain Research Center, 4-13-18 Jiyugaoka, Hofu 7470066, Yamaguchi, Japan.
Received: February 17, 2025
Revised: March 20, 2025
Accepted: April 14, 2025
Published online: July 19, 2025
Processing time: 145 Days and 22.9 Hours
Revised: March 20, 2025
Accepted: April 14, 2025
Published online: July 19, 2025
Processing time: 145 Days and 22.9 Hours
Core Tip
Core Tip: Acute skin failure tends to cause insomnia and anxiety. The skin, along with the gut, is an organ that functions as a barrier, forming the gut-skin-brain axis. The gut-skin-brain axis is a bidirectional relationship mediated by the immune system, hormones, and the autonomic nervous system. Studying the gut-skin-brain axis holds immense promise for understanding mental illness due to the intricate and bidirectional communication network it represents. In essence, the gut-skin-brain axis provides a framework for understanding how interactions between the gut, skin, and brain can influence mental health, opening new avenues for prevention and treatment.