Basic Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Jun 19, 2025; 15(6): 104809
Published online Jun 19, 2025. doi: 10.5498/wjp.v15.i6.104809
Modulating oral microbiota ameliorates hypobaric hypoxia-induced anxiety- and depression-like behaviors in mice
Wen-Yue Chang, Qiao-Zhen Qin, Xiao-Tong Li, Jia-Jing Wang, Yue Chen, Hua-Qiang Ruan, Yan-Nv Qu, Xiao-Xia Jiang, Hui-Xia He
Wen-Yue Chang, Hui-Xia He, Department of Stomatology, First Medical Center of Chinese PLA General Hospital and Medical School of Chinese PLA, Beijing 100853, China
Qiao-Zhen Qin, Xiao-Tong Li, Yue Chen, Hua-Qiang Ruan, Xiao-Xia Jiang, Institute of Basic Medical Sciences, Beijing 100850, China
Jia-Jing Wang, Strategic Support Force Characteristic Medical Center of Chinese PLA, Beijing 100101, China
Yan-Nv Qu, Department of Geriatrics, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong Province, China
Co-corresponding authors: Xiao-Xia Jiang and Hui-Xia He.
Author contributions: Jiang XX and He HX contribute equally to this study as co-corresponding authors; Jiang XX was responsible for supervision, writing - review & editing, funding acquisition, resources; He HX was responsible for supervision, resources; Chang WY was responsible for conceptualization, investigation, writing - original draft, methodology, formal analysis; Qin QZ was responsible for data curation, software; Li XT was responsible for investigation, methodology; Wang JJ was responsible for validation; Chen Y was responsible for project administration; Ruan HQ was responsible for writing - review & editing; Qu YN was responsible for funding acquisition.
Supported by Guangdong Basic and Applied Basic Research Foundation, No. 2023A1515012394.
Institutional animal care and use committee statement: All animal experiments were conducted according to the Guide for the Care and Use of Laboratory Animals by the Administrative Panel on Laboratory Animal Care at the Institute of Basic Medical Sciences (Beijing, China, No. IACUC-DWZX-2024-530).
Conflict-of-interest statement: The author(s) report no conflict of interest in this work.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hui-Xia He, Department of Stomatology, First Medical Center of Chinese PLA General Hospital and Medical School of Chinese PLA, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. hehuixia@301hospital.com.cn
Received: January 2, 2025
Revised: March 11, 2025
Accepted: April 21, 2025
Published online: June 19, 2025
Processing time: 147 Days and 7.2 Hours
Core Tip

Core Tip: The effects of hypobaric hypoxia (HH) exposure (HHE) on anxiety- and depression-like behaviors in mice were analyzed. HHE for one day activated several brain nuclei, including the anterior cingulate cortex, paraventricular thalamic nucleus, lateral habenula, paraventricular hypothalamic nucleus, lateral hypothalamus, and anterior periaqueductal gray. A significant decrease in Lactobacillus abundance was found in the oral microbiota following one day of HH. Both oral application and gavage administration of a Lactobacillus complex effectively alleviated anxiety- and depression-like behaviors in mice subjected to one day of HH.