Diagnostic dynamic contrast-enhanced magnetic resonance imaging blood-brain barrier assessment combined with plasma biomarkers for mild cognitive impairment

doi:10.5498/wjp.v15.i6.103661

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Jun 19, 2025 (publication date) through May 29, 2025

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Observational Study

World J Psychiatry. Jun 19, 2025; 15(6): 103661
Published online Jun 19, 2025. doi: 10.5498/wjp.v15.i6.103661

Diagnostic dynamic contrast-enhanced magnetic resonance imaging blood-brain barrier assessment combined with plasma biomarkers for mild cognitive impairment

Ling Sun, Meng-Rong Xu, Cheng-Yu Zhou, Shao-Dong Cao, Xiao-Liang Zhang, Si-Qi Guan, Wen-Xu Sang, Xu-Ling Li

Ling Sun, Meng-Rong Xu, Cheng-Yu Zhou, Xiao-Liang Zhang, Si-Qi Guan, Wen-Xu Sang, Xu-Ling Li, Department of Neurology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150000, Heilongjiang Province, China

Shao-Dong Cao, Department of Radiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150000, Heilongjiang Province, China

Author contributions: Sun L designed the research and wrote the draft of the manuscript; Sun L, Xu MR, Zhou CY, Cao SD, Zhang XL, Guan SQ, Sang WX and Li XL conceived the research and analyzed data; Sun L and Li XL performed analysis and provided guidance for the research; All authors reviewed and approved the final manuscript.

Institutional review board statement: This study was approved by the Ethics Committee of the Fourth Affiliated Hospital of Harbin Medical University (No. YXLLSC-2018-19).

Informed consent statement: All study participants or their legal guardian provided informed written consent prior to study enrollment.

Conflict-of-interest statement: The authors declare that they have no conflict of interest.

STROBE statement: The authors have read the STROBE Statement—a checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-a checklist of items.

Data sharing statement: No additional data are available.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Xu-Ling Li, MD, Doctor, Department of Neurology, The Fourth Affiliated Hospital of Harbin Medical University, No. 37 Yiyuan Street, Nangang District, Harbin 150000, Heilongjiang Province, China. hydlixuling@126.com

Received: March 5, 2025
Revised: March 31, 2025
Accepted: May 7, 2025
Published online: June 19, 2025
Processing time: 85 Days and 2.4 Hours

Core Tip

Core Tip: Mild cognitive impairment (MCI) is considered a transitional state between normal aging and dementia and has several contributing factors. Recent literature indicates that blood-brain barrier (BBB) damage may play a key role in MCI, providing new targets for therapeutic intervention. Currently, magnetic resonance imaging (MRI) techniques are predominantly used for BBB integrity assessment. This study uses dynamic contrast-enhanced MRI to calculate BBB permeability and combines biochemical indicators to understand BBB damage in patients with MCI.