Hendi M, Zhang B, Lv JM, Cai XJ. Factors influencing anxiety and depression in advanced hepatocellular carcinoma patients and their impact on quality of life. World J Psychiatry 2025; 15(5): 104995 [DOI: 10.5498/wjp.v15.i5.104995]
Corresponding Author of This Article
Xiu-Jun Cai, FACS, FRCS, MD, PhD, Professor, Department of General Surgery, Zhejiang University School of Medicine, Sir Run Run Shaw Hospital, No. 3 East Qingchun Road, Hangzhou 310016, Zhejiang Province, China. srrs_cxj@163.com
Research Domain of This Article
Psychiatry
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Psychiatry. May 19, 2025; 15(5): 104995 Published online May 19, 2025. doi: 10.5498/wjp.v15.i5.104995
Factors influencing anxiety and depression in advanced hepatocellular carcinoma patients and their impact on quality of life
Maher Hendi, Bin Zhang, Jie-Min Lv, Xiu-Jun Cai
Maher Hendi, Bin Zhang, Jie-Min Lv, Xiu-Jun Cai, Department of General Surgery, Zhejiang University School of Medicine, Sir Run Run Shaw Hospital, Hangzhou 310016, Zhejiang Province, China
Author contributions: Hendi M and Cai XJ drafted the manuscript and gave final approval of the version to be published; Hendi M, Zhang B, Lv JM, and Cai XJ designed this study, collected and analyzed the data; and all authors thoroughly reviewed and endorsed the final manuscript.
Institutional review board statement: This study was approved by the ethic institutional review board of the Zhejiang University School of Medicine, Sir Run Run Shaw Hospital, approval No. 2024-013-01.
Informed consent statement: The informed consent was waived by the ethic institutional review board of the Zhejiang University School of Medicine, Sir Run Run Shaw Hospital.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: All the data were generated and analyzed by the authors, and further inquiries can be directed to the corresponding author.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiu-Jun Cai, FACS, FRCS, MD, PhD, Professor, Department of General Surgery, Zhejiang University School of Medicine, Sir Run Run Shaw Hospital, No. 3 East Qingchun Road, Hangzhou 310016, Zhejiang Province, China. srrs_cxj@163.com
Received: January 10, 2025 Revised: February 19, 2025 Accepted: April 8, 2025 Published online: May 19, 2025 Processing time: 110 Days and 0.3 Hours
Core Tip
Core Tip: Patients middle and advanced hepatocellular carcinoma (HCC) often experience significant anxiety and depression, which may severely affect their quality of life. This study assessed the anxiety and depression status of patients middle and advanced HCC and their influencing factors, analyzing the correlation between these psychological factors and quality of life. According to the results, a large number of advanced HCC patients suffer from depression and anxiety, which are negatively associated with social support and a high quality of life. Hamilton Anxiety Rating Scale and Hamilton Depression Rating Scale scores, prior liver resection, Barcelona Clinic Liver Cancer C stage, and multiple tumors are risk factors for depression in advanced HCC patients. Meanwhile, Karnofsky performance scores are negatively correlated with anxiety, and independent risk factors for anxiety include age over 60, a history of alcohol consumption, Hamilton Anxiety Rating Scale and Hamilton Depression Rating Scale scores, prior liver resection, Barcelona Clinic Liver Cancer C stage, and multiple tumors. Anxiety and depression scores in liver cancer patients are negatively correlated with quality of life.
