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Li RT, Lan BJ, Xiao ZY, Shi QH, Chen XY, Li F. Sini-Suanzaoren decoction regulates mitochondrial biogenesis mediated by MT-SIRT1 in the treatment of insomnia rats. World J Psychiatry 2025; 15(12): 108867 [PMID: 41357936 DOI: 10.5498/wjp.v15.i12.108867]
Ru-Ting Li, Bi-Juan Lan, Zhuo-Yang Xiao, Qing-Huan Shi, Xin-Yi Chen, Feng Li, School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102488, China
Author contributions: Li RT initiated the project, designed the experiment and conducted data collection; Li RT, Lan BJ, Shi QH and Chen XY participated in animal experimentation; Li RT and Xiao ZY conducted the collation and statistical analysis, and wrote the original manuscript; Li F make critical revisions to important knowledge content; all authors read and approved the final manuscript.
Supported by the Beijing Natural Science Foundation, No. 7232289.
Institutional animal care and use committee statement: The study was approved by the Animal Ethics Committee of Beijing University of Chinese Medicine (No. BUCM-2024050806-2107).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: All data generated or analyzed during this study are included in this published article.
Corresponding author: Feng Li, PhD, School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, No. 11 North Third Ring East Road, Chaoyang District, Beijing 102488, China. lifeng_bucm0610@126.com
Received: July 1, 2025 Revised: August 6, 2025 Accepted: September 19, 2025 Published online: December 19, 2025 Processing time: 149 Days and 1.4 Hours
Core Tip
Core Tip: This study pioneers the scientific validation of Sini-Suanzaoren decoction (SNSZRD) for insomnia by bridging traditional Chinese medicine (TCM) theory with mitochondrial pathophysiology. We identify 8 blood-brain barrier-penetrating components (e.g., senkyunolide G) that activate the MT-SIRT1 pathway, reversing neuronal mitochondrial dysfunction via dose-dependent upregulation of PPARγ coactivator-1α/nuclear respiratory factor-1/mitochondrial transcription factor A. Crucially, we decode TCM principles: "Soothing liver depression" corresponds to SIRT1 stabilization, while "nourishing heart-spirit" aligns with ATP-dependent synaptic repair. This work establishes SNSZRD as a multi-target mitochondrial regulator, offering novel biomarkers (hypothalamic ATP) and lead compounds for insomnia therapeutics.
