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Kalawatia M, Mehrunkar A, Lucke-Wold B. Harnessing resilience in patient treatment and long-term recovery: Psychosocial and neurobiological pathways to enhanced outcomes. World J Psychiatry 2025; 15(10): 109462 [PMID: 41112628 DOI: 10.5498/wjp.v15.i10.109462]
Mihit Kalawatia, Department of Neurosurgery, Rajarshi Chattrapati Shahu Maharaj Government Medical College, Kolhapur 416003, Maharashtra, India
Aabhali Mehrunkar, Department of Psychiatry, Rajarshi Chattrapati Shahu Maharaj Government Medical College, Kolhapur 416003, Maharashtra, India
Brandon Lucke-Wold, Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, FL 32608, United States
Co-corresponding authors: Mihit Kalawatia and Brandon Lucke-Wold.
Author contributions: Kalawatia M contributed to the manuscript with conceptualization, literature review, data collection, manuscript drafting, and critical revision; Mehrunkar A contributed to the manuscript with data analysis, visualization, manuscript editing, and proofreading; Lucke-Wold B contributed to the manuscript with methodology, supervision, final review, manuscript touch-ups, and project supervision; Kalawatia M and Lucke-Wold B contributed equally to this article, they are the co-corresponding authors of this manuscript; and all authors have read and approved the final version of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Brandon Lucke-Wold, Lillian S. Wells Department of Neurosurgery, University of Florida, 1505 SW Archer Rd, Gainesville, FL 32608, United States. brandon.lucke-wold@neurosurgery.ufl.edu
Received: May 12, 2025 Revised: June 25, 2025 Accepted: August 6, 2025 Published online: October 19, 2025 Processing time: 137 Days and 14.1 Hours
Core Tip
Core Tip: Targeted interventions combining psychosocial support with neurobiological strategies can enhance resilience, improving coping, adherence, and recovery in patients facing serious health challenges. Initiating these strategies early and sustaining them throughout treatment maximizes their benefits. Using psychometric scales, biomarkers, and digital monitoring offers a comprehensive view of adaptive capacity. Multidisciplinary teams - including oncology, palliative care, and allied health - deliver culturally tailored interventions. Establishing unified definitions, standardized measurements, and scalable models through longitudinal research and supportive policies will embed resilience as a fundamental component of compassionate healthcare.
