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Fang RY, Pan XR, Zeng XX, Li ZZ, Chen BF, Zeng HM, Peng J. Gut-brain axis as a bridge in obesity and depression: Mechanistic exploration and therapeutic prospects. World J Psychiatry 2025; 15(1): 101134 [PMID: 39831021 DOI: 10.5498/wjp.v15.i1.101134]
Rui-Ying Fang, Xiao-Rui Pan, Xin-Xing Zeng, Zheng-Zheng Li, Bo-Fan Chen, Hai-Min Zeng, Jie Peng, The Second Clinical Medical College, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, Jiangxi Province, China
Co-first authors: Rui-Ying Fang and Xiao-Rui Pan.
Author contributions: Peng J designed and implemented the content of this manuscript; Fang RY and Pan XR wrote the manuscript; Zeng XX, Li ZZ, Chen BF and Zeng HM contributed to this paper; Peng J revised and reviewed the manuscript. All authors reviewed and approved the final version of the manuscript. Fang RY and Pan XR contributed equally to this work as co-first authors.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Corresponding author: Jie Peng, MD, Doctor, The Second Clinical Medical College, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 1 Minde Road, Donghu District, Nanchang 330006, Jiangxi Province, China. jie_peng@email.ncu.edu.cn
Received: September 5, 2024 Revised: November 2, 2024 Accepted: November 18, 2024 Published online: January 19, 2025 Processing time: 104 Days and 4.9 Hours
Core Tip
Core Tip: The gut-brain axis is a crucial pathway that links the intestines to the brain and influences host health through microbial metabolites, neural signals, immune responses, and endocrine pathways. Metabolic byproducts of microbes, such as short-chain fatty acids, lipopolysaccharide and bile acids, modulate appetite, emotional regulation, and immune-inflammatory responses via the gut-brain axis and are closely associated with the onset and progression of obesity and depression. Modulating the gut-brain axis, for example, through the use of prebiotics, specific ketogenic diet, and the supplementation of antioxidants, provides new therapeutic strategies for obesity and depression. Future research needs to delve deeper into the mechanisms of the gut-brain axis to develop more effective interventions.
