Exosomal miR-320e through wnt2targeted inhibition of the Wnt/β-catenin pathway allevisate cerebral small vessel disease and cognitive impairment
Zheng Wang, Department of Internal Medicine-Neurology, Affiliated Hospital of Qingdao University, Qingdao 266001, Shandong Province, China
Xue-Ning Li, Shao-Nan Yang, Yuan Wang, Ke-Jin Gao, Bin Han, Ai-Jun Ma, Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao 266001, Shandong Province, China
Author contributions: Wang Z and Li XN concepted the study; Wang Z, Yang SN and Wang Y collected the data; Wang Z, Gao KJ, Han B and Ma AJ contributed to the formal analysis; Wang Z and Ma AJ contributed to the investigation; Wang Z, Li XN and Wang Y contributed to the methodology; Wang Z, Han B, Gao KJ and Ma AJ supervised the study; Yang SN validated the study; Wang Z and Yang SN contributed to the visualization of the study; Wang Z and Han B originally drafted the manuscript; Wang Z, Li XN, Yang SN, Wang Y Gao KJ Han B and Ma AJ reviewed and edited the manuscript.
Institutional review board statement: The study has passed the ethical review of Qingdao University Affiliated Hospital.
Informed consent statement: All specimens were collected after obtaining authorization from the patients and their families and signing a consent form.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ai-Jun Ma, MD, Attending Doctor, Department of Neurology, The Affiliated Hospital of Qingdao University, No.16 Jiangsu Street, Qingdao 266001, Shandong Province, China. firstname.lastname@example.org
Received: May 24, 2023
Peer-review started: May 24, 2023
First decision: June 12, 2023
Revised: June 20, 2023
Accepted: July 14, 2023
Article in press: July 14, 2023
Published online: September 19, 2023