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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Aug 19, 2022; 12(8): 1016-1030
Published online Aug 19, 2022. doi: 10.5498/wjp.v12.i8.1016
Published online Aug 19, 2022. doi: 10.5498/wjp.v12.i8.1016
Antidepressants combined with psychodrama improve the coping style and cognitive control network in patients with childhood trauma-associated major depressive disorder
Ren-Qiang Yu, Huan Tan, Fa-Jin Lv, Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
Er-Dong Wang, College of Art, Soochow University, Suzhou 215006, Jiangsu Province, China
Jie Huang, Pei-Jia Wang, Xiao-Mei Li, Han-Han Zheng, Hua Hu, Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing 40016, China
Author contributions: All authors have materially participated in the research and article preparation; Yu RQ and Tan H participated in data collection, analysis, paper writing, and have equally contributed to this work; Wang ED implemented psychodrama intervention; Huang J, Wang PJ, Li XM, Zheng HH, and Lv FJ participated in data collection and analysis; Hu H, in charge of the research, was responsible for project application, implementation, and article writing; All authors approved the final manuscript.
Institutional review board statement: All patients provided written informed consent, and the study was approved by the Ethics Committee of the First Affiliated Hospital of Chongqing Medical University.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hua Hu, PhD, Doctor, Professor, Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuanjiagang, Yuzhong District, Chongqing 400016, China. huhuateam@126.com
Received: March 22, 2022
Peer-review started: March 22, 2022
First decision: June 11, 2022
Revised: July 27, 2022
Accepted: July 27, 2022
Article in press: July 27, 2022
Published online: August 19, 2022
Peer-review started: March 22, 2022
First decision: June 11, 2022
Revised: July 27, 2022
Accepted: July 27, 2022
Article in press: July 27, 2022
Published online: August 19, 2022
Core Tip
Core Tip: Antidepressant therapy alone has limited efficacy in patients with childhood trauma-associated major depressive disorder. In our study, we treated patients with childhood trauma-associated major depressive disorder with antidepressants combined with psychodrama. After treatment, the internal connectivity of the cognitive control network increased in patients with childhood trauma-associated depression. Antidepressants combined with psychodrama were more effective in improving patients’ coping styles and cognitive control network than combined with a general health education intervention.