Neuroimmune crosstalk through brain-derived neurotrophic factor and its precursor pro-BDNF: New insights into mood disorders

doi:10.5498/wjp.v12.i3.379

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World Journal of Psychiatry

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World J Psychiatry. Mar 19, 2022; 12(3): 379-392
Published online Mar 19, 2022. doi: 10.5498/wjp.v12.i3.379

Neuroimmune crosstalk through brain-derived neurotrophic factor and its precursor pro-BDNF: New insights into mood disorders

Xiao-Pei Zhao, Hui Li, Ru-Ping Dai

Xiao-Pei Zhao, Hui Li, Ru-Ping Dai, Department of Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China

Author contributions: Zhao XP collected the data and wrote the paper; Li H and Dai RP collected the data and supervised the writing of the paper.

Supported by National Natural Science Foundation of China, No. 82071347 and No. 81771354 (to Dai RP).

Conflict-of-interest statement: The authors declare no conflict of interest.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Ru-Ping Dai, MD, PhD, Academic Research, Chief Doctor, Director, Doctor, Professor, Department of Anesthesiology, The Second Xiangya Hospital, Central South University, No. 139 Renmin Middle Road, Changsha 410011, Hunan Province, China. xyeyyrupingdai@csu.edu.cn

Received: March 29, 2021
Peer-review started: March 29, 2021
First decision: August 19, 2021
Revised: August 22, 2021
Accepted: January 22, 2022
Article in press: January 22, 2022
Published online: March 19, 2022

Core Tip

Core Tip: The neuroimmune crosstalk plays a crucial role in the regulation of mood disorders. Recent studies have shown that the brain-derived neurotrophic factor (BDNF) and its precursor pro-BDNF are cardinal regulators in the neuroimmune axis. However, the roles and potential mechanisms of BDNF/pro-BDNF signaling in the neuroimmune crosstalk in the context of mood disorders remain unexplored. In this review, we summarize recent studies on the role of BDNF/TrkB signaling and pro-BDNF/p75^NTR signaling in the neuroimmune axis and how they influence the development of mood disorders.