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World J Psychiatry. Jan 19, 2022; 12(1): 98-107
Published online Jan 19, 2022. doi: 10.5498/wjp.v12.i1.98
Molecular typing of familial temporal lobe epilepsy
Chao Liu, Xiao-Zhi Qiao, Zi-Han Wei, Mi Cao, Zhen-Yu Wu, Yan-Chun Deng
Chao Liu, Xiao-Zhi Qiao, Zi-Han Wei, Mi Cao, Yan-Chun Deng, Department of Neurology, The First Affiliated Hospital of Air Force Medical University, Xi'an 710032, Shaanxi Province, China
Zhen-Yu Wu, Department of Anatomy, Histology and Embryology and K.K. Leung Brain Research Centre, School of Basic Medicine, Air Force Medical University, Xi'an 710032, Shaanxi Province, China
Author contributions: Liu C and Qiao XZ drafted the manuscript; Wei ZH, Cao M and Wu ZY helped with information retrieval; Deng YC conceived this review and provided essential revisions; all authors reviewed the paper.
Supported by the National Key R&D Program of China, Precision Medicine Program -Cohort Study on Nervous System Diseases, No. 2017YFC0907702.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan-Chun Deng, MD, PhD, Chief Doctor, Professor, Department of Neurology, The First Affiliated Hospital of Air Force Medical University, No. 127 Changle West Road, Xi'an 710032, Shaanxi Province, China. yanchund@fmmu.edu.cn
Received: February 28, 2021
Peer-review started: February 28, 2021
First decision: September 5, 2021
Revised: September 25, 2021
Accepted: December 2, 2021
Article in press: December 2, 2021
Published online: January 19, 2022
Core Tip

Core Tip: Eleven types of familial temporal lobe epilepsy (FTLE) caused by single gene mutations or specific gene loci had been identified to date. The phenotype of FTLE was heterogenous and includes typical temporal lobe seizures and specific symptoms. We herein describe the etiology, inheritance, phenotype and prognosis of each type of FTLE and summarize their similarities and differences.