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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatr. Sep 19, 2021; 11(9): 659-680
Published online Sep 19, 2021. doi: 10.5498/wjp.v11.i9.659
Published online Sep 19, 2021. doi: 10.5498/wjp.v11.i9.659
Deep brain stimulation for obsessive-compulsive disorder: A systematic review of worldwide experience after 20 years
Lorea Mar-Barrutia, Eva Real, Cinto Segalás, Sara Bertolín, José Manuel Menchón, Pino Alonso, OCD Clinical and Research Unit, Department of Psychiatry, Hospital de Bellvitge, Barcelona 08907, Spain
Eva Real, Cinto Segalás, José Manuel Menchón, Pino Alonso, Bellvitge Biomedical Research Institute-IDIBELL, Barcelona 08907, Spain
Eva Real, Cinto Segalás, José Manuel Menchón, Pino Alonso, CIBERSAM (Centro de Investigación en Red de Salud Mental), Carlos III Health Institute, Madrid 28029, Spain
José Manuel Menchón, Pino Alonso, Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona 08907, Spain
Author contributions: Alonso P and Real E designed the research; Mar-Barrutia L and Bertolín S performed the research; Mar-Barrutia L, Segalás C and Bertolín S analyzed the data; Mar-Barrutia L and Alonso P wrote the paper; Menchón JM supervised the paper; all authors read and approved the final manuscript.
Supported by Carlos III Health Institute , No. PI16/00950 and No. PI18/00856 ; and FEDER funds (‘A way to build Europe’).
Conflict-of-interest statement: All the authors declare that they have no competing interests.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Pino Alonso, PhD, Senior Researcher, OCD Clinical and Research Unit, Department of Psychiatry, Hospital de Bellvitge, C/Feixa Llarga s/n, Barcelona 08907, Spain. mpalonso@bellvitgehospital.cat
Received: February 28, 2021
Peer-review started: February 28, 2021
First decision: April 20, 2021
Revised: May 2, 2021
Accepted: August 18, 2021
Article in press: August 18, 2021
Published online: September 19, 2021
Peer-review started: February 28, 2021
First decision: April 20, 2021
Revised: May 2, 2021
Accepted: August 18, 2021
Article in press: August 18, 2021
Published online: September 19, 2021
Core Tip
Core Tip: This systematic review describes worldwide experience in the use of deep brain stimulation (DBS) in severe resistant patients with obsessive-compulsive disorder over the last twenty years, comparing short-term (ST) and long-term (LT) response to the treatment (in 230 and 155 patients respectively). Both ST and LT studies report similar, stable reductions in severity of around 47%, although the number of patients who met the criteria for response was significantly higher in the LT studies (60.6% vs 70.7%). DBS is a safe and well-tolerated technique, since most side effects are mild and reversible on adjusting stimulation parameters. However, no clear predictors of response can be established at present.