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World J Psychiatr. Sep 19, 2021; 11(9): 553-567
Published online Sep 19, 2021. doi: 10.5498/wjp.v11.i9.553
Is there a place for cellular therapy in depression?
Pedro Antônio Schmidt do Prado-Lima, Zaquer Suzana Munhoz Costa-Ferro, Bruno Solano de Freitas Souza, Ivana Beatrice Manica da Cruz, Biogenomics Lab
Pedro Antônio Schmidt do Prado-Lima, Zaquer Suzana Munhoz Costa-Ferro, Brain Institute of Rio Grande do Sul (BraIns), Pontifical Catholic University of Rio Grande do Sul, Porto Alegre 90610-000, Rio Grande do Sul, Brazil
Zaquer Suzana Munhoz Costa-Ferro, Bruno Solano de Freitas Souza, Center for Biotechnology and Cell Therapy, São Rafael Hospital, Salvador 41253-190, Bahia, Brazil
Zaquer Suzana Munhoz Costa-Ferro, Bruno Solano de Freitas Souza, D’Or Institute for Research and Education (IDOR), Salvador 41253-190, Bahia, Brazil
Bruno Solano de Freitas Souza, Laboratory of Tissue Engineering and Immunopharmacology, Gonçalo Moniz Institute, Fiocruz, Salvador 40296-710, Bahia, Brazil
Ivana Beatrice Manica da Cruz, Biogenomics Lab, Health Sciences Center, Federal University of Santa Maria, Santa Maria 97105900, RS, Brazil
Author contributions: do Prado-Lima PAS was responsible for the overall organization of the manuscript structure and writing and reviewing the epidemiological part of depression and the inflammatory role in this psychiatric disorder for the survey and comments related to clinical trials involving stem cell depression that are in progress; Costa-Ferro ZSM and Souza BSDF were responsible for compiling, organizing, and description of the tables related to the main studies involving stem cells in depression and other associated diseases; da Cruz IBM was also responsible for reviewing the neuroinflammatory aspects related to depression, the general organization of the figure, formatting, and submission of the manuscript; all authors contributed to the general writing, revising the text, and scientific quality of the manuscript.
Supported by Conselho Nacional de Desenvolvimento Cientifico -CNPq.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Pedro Antônio Schmidt do Prado-Lima, PhD, Academic Research, Brain Institute of Rio Grande do Sul (BraIns), Pontifical Catholic University of Rio Grande do Sul, Avenida Ipiranga 6690, Porto Alegre 90610-000, Rio Grande do Sul, Brazil. paspl@uol.com.br
Received: February 28, 2021
Peer-review started: February 28, 2021
First decision: April 20, 2021
Revised: May 5, 2021
Accepted: August 13, 2021
Article in press: August 13, 2021
Published online: September 19, 2021
Core Tip

Core Tip: In this study, the authors performed a narrative review regarding the role of inflammation in depression and investigated the evidence suggesting that the use of stem cell therapies could be a realistic, safe, and effective strategy for treating depression.