Retrospective Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatr. Apr 19, 2021; 11(4): 124-132
Published online Apr 19, 2021. doi: 10.5498/wjp.v11.i4.124
Chronic serotonin syndrome: A retrospective study
Sanjay Prakash, Chaturbhuj Rathore, Kaushik Rana, Diptangshu Roychowdhury, Deepali Lodha
Sanjay Prakash, Chaturbhuj Rathore, Kaushik Rana, Department of Neurology, Smt. B.K. Shah Medical Institute and Research Centre, Sumandeep Vdyapeeth, Vadodara 391760, India
Diptangshu Roychowdhury, Department of Psychiatry, Smt. B.K. Shah Medical Institute and Research Centre, Sumandeep Vdyapeeth, Vadodara 391760, India
Deepali Lodha, Department of Medicine, Smt. B.K. Shah Medical Institute and Research Centre, Sumandeep Vdyapeeth, Vadodara 391760, India
Author contributions: Prakash S was involved in the conceptualization of the project, data collection, statistical analysis, supervision of the project, and writing the original draft; Rathore C was involved in the analysis and interpretation of data and writing the original draft; Rana K was involved in the analysis and interpretation of data and revising the manuscript for intellectual content; Roychowdhury D was involved in data collection and revising the manuscript for intellectual content; Lodha D was involved in data collection and revising the manuscript for intellectual content; All authors approved the final manuscript.
Institutional review board statement: The study was reviewed and approved by the Sumandeep Vidyapeeth Institutional Ethics committee, Piparia, Vadodara, India (SVIEC/ON/MEDI/RP/20116).
Informed consent statement: Written informed consent was taken from all patients to publish this observation.
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sanjay Prakash, MD, Professor, Department of Neurology, Smt. B.K. Shah Medical Institute and Research Centre, Sumandeep Vdyapeeth, Piparia, Waghodia, Vadodara 391760, India. drprakashs@yahoo.co.in
Received: December 14, 2020
Peer-review started: December 14, 2020
First decision: January 18, 2021
Revised: January 21, 2021
Accepted: March 9, 2021
Article in press: March 9, 2021
Published online: April 19, 2021
Core Tip

Core Tip: Chronic serotonin syndrome (SS) is an evolving concept. It may present with nonspecific symptoms such as generalized body pain, stiffness/rigidity, insomnia, restlessness, and tiredness. As misdiagnosis is common for typical cases of SS, a high level of clinical suspicion is required to identify patients with a chronic variant. A detailed drug history and thorough physical examinations are needed to detect a case of SS. Diagnosis of even mild SS is important as inadvertent use of another serotonergic agent may worsen the clinical symptoms, and sometimes it can be fatal.