Selective ablation of type 3 adenylyl cyclase in somatostatin-positive interneurons produces anxiety- and depression-like behaviors in mice
Xiao-Yu Yang, Zhao-Liang Ma, Hong Cao, Yu-Qiu Zhang, Department of Translational Neuroscience, Jing’an District Centre Hospital of Shanghai, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Institutes of Integrative Medicine, Fudan University, Shanghai 200032, China
Daniel R Storm, Department of Pharmacology, University of Washington, Seattle, WA 98105, United States
Author contributions: Yang XY and Cao H designed and coordinated the study; Yang XY and Ma ZL performed the experiments, acquired, and analyzed data; Storm DR provided the Floxed AC3 mice; Cao H and Zhang YQ interpreted the data; Yang XY, Storm DR and Cao H wrote the manuscript; All authors approved the final version of the article.
Supported by National Natural Science Foundation of China, No. 81771208 and No. 81971043
Institutional animal care and use committee statement: The study was reviewed and approved by the Experimental Animal Ethics Committee of Shanghai Medical College and the Institutional Animal Care & Use Committee (IACUC) of Fudan University (permit No. 20170223-091). All experimental procedures were designed to minimize pain or discomfort to the animals and followed the ethical guidelines of the International Association for the Study of Pain regarding the use of laboratory animal.
Conflict-of-interest statement: All authors have no any conflicts of interest.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE Guidelines, and the manuscript was prepared and revised according to the ARRIVE Guidelines.
: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hong Cao, MD, PhD, Associate Professor, Department of Translational Neuroscience, Jing’an District Centre Hospital of Shanghai, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Institutes of Integrative Medicine, Fudan University, Rm 1202 Mingdao Building, No. 131 Dong'an Road, Shanghai 200032, China. email@example.com
Received: October 13, 2020
Peer-review started: October 13, 2020
First decision: December 4, 2020
Revised: December 9, 2020
Accepted: December 24, 2020
Article in press: December 24, 2020
Published online: February 19, 2021