Published online Nov 19, 2021. doi: 10.5498/wjp.v11.i11.1053
Peer-review started: May 7, 2021
First decision: June 5, 2021
Revised: June 10, 2021
Accepted: August 30, 2021
Article in press: August 30, 2021
Published online: November 19, 2021
Core Tip: Generally, in dentistry, uncomfortable occlusal sensations are a common finding among patients while phantom bite syndrome (which is distinguishable if ever encountered) is quite rare. These patients present with non-verifiable occlusal discrepancies with strict demands for bite correction and remarkable psychological distress. This might lead to serious consequences on patients’ life quality, relationship with family, financial loss, career disruption or even suicidal thoughts. Recent studies have revealed unexplained diversity patterns among phantom bite syndrome’s clinical manifestation and functional brain imaging, which likely represent the available sub-phenotypes of this syndrome. Further research must be focused on elucidating pathophysiological mechanisms to pave the way for efficient treatment strategy.