Published online Oct 19, 2021. doi: 10.5498/wjp.v11.i10.830
Peer-review started: February 28, 2021
First decision: March 30, 2021
Revised: April 11, 2021
Accepted: August 3, 2021
Article in press: August 3, 2021
Published online: October 19, 2021
Core Tip: Dopaminergic neurotoxicity is characterized by damage and death of dopaminergic neurons. Chronic systemic exposure to rotenone (an inhibitor of mitochondrial complex I and a commonly used pesticide) induced dopaminergic degeneration and reproduced many features of human Parkinson's disease in rats. The current paper aims to review the involvement of metabotropic glutamate receptors and the contribution nitric oxide to dopaminergic neurotoxicity.