Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatr. Oct 19, 2021; 11(10): 830-840
Published online Oct 19, 2021. doi: 10.5498/wjp.v11.i10.830
Metabotropic glutamate receptors and nitric oxide in dopaminergic neurotoxicity
Valentina Bashkatova
Valentina Bashkatova, Laboratory of Physiology Reinforcements, Anokhin Institute of Normal Physiology, Moscow 125315, Russia
Author contributions: Bashkatova V wrote the paper.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Valentina Bashkatova, PhD, Professor, Laboratory of Physiology Reinforcements, Anokhin Institute of Normal Physiology, 8 Baltiyskaya str., Moscow 125315, Russia.
Received: February 28, 2021
Peer-review started: February 28, 2021
First decision: March 30, 2021
Revised: April 11, 2021
Accepted: August 3, 2021
Article in press: August 3, 2021
Published online: October 19, 2021
Core Tip

Core Tip: Dopaminergic neurotoxicity is characterized by damage and death of dopaminergic neurons. Chronic systemic exposure to rotenone (an inhibitor of mitochondrial complex I and a commonly used pesticide) induced dopaminergic degeneration and reproduced many features of human Parkinson's disease in rats. The current paper aims to review the involvement of metabotropic glutamate receptors and the contribution nitric oxide to dopaminergic neurotoxicity.