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Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatr. Oct 19, 2021; 11(10): 805-820
Published online Oct 19, 2021. doi: 10.5498/wjp.v11.i10.805
Connecting brain and body: Transdiagnostic relevance of connective tissue variants to neuropsychiatric symptom expression
Harriet Emma Clare Sharp, Hugo D Critchley, Jessica A Eccles
Harriet Emma Clare Sharp, Hugo D Critchley, Jessica A Eccles, Department of Medical Neuroscience, Brighton and Sussex Medical School, University of Sussex, Brighton BN1 9PX, East Sussex, United Kingdom
Harriet Emma Clare Sharp, Hugo D Critchley, Jessica A Eccles, Department of Psychiatry, Sussex Partnership NHS Foundation Trust, Worthing, BN13 3EP, West Sussex, United Kingdom
Author contributions: Sharp HEC, Critchley HD and Eccles JA equally shaped the ideas and structure of this review; Sharp HEC searched the relevant literature and took the lead in writing the manuscript; Sharp HEC, Critchley HD and Eccles JA provided full input to and critical feedback of the final manuscript; all authors have read and approved the final manuscript.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hugo D Critchley, DPhil, MBChB, Professor, Department of Medical Neuroscience, Brighton and Sussex Medical School, University of Sussex, Brighton BN1 9PX, East Sussex, United Kingdom. h.critchley@bsms.ac.uk
Received: February 26, 2021
Peer-review started: February 26, 2021
First decision: April 20, 2021
Revised: May 12, 2021
Accepted: August 18, 2021
Article in press: August 18, 2021
Published online: October 19, 2021
Core Tip

Core tip: The association between vulnerability to psychological or psychiatric symptoms and hypermobile joints may initially appear counterintuitive to many clinicians. However, a relationship with anxiety is consistently confirmed across multiple studies worldwide. In this narrative review, we appraise increasing evidence linking neuropsychiatric presentations to hypermobility across the lifespan, including emerging links to neurodevelopmental disorders and stress-sensitive medical conditions. We discuss pertinent mechanistic insights in the context of growing understanding of mind-body interactions. We offer direction for future research and highlight implications for clinical practice, notably roles of timely screening and detection alongside longer-term holistic management strategies.