Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatr. Oct 19, 2021; 11(10): 711-735
Published online Oct 19, 2021. doi: 10.5498/wjp.v11.i10.711
Alternative models for transgenerational epigenetic inheritance: Molecular psychiatry beyond mice and man
Gary R Hime, Sophie LA Stonehouse, Terence Y Pang
Gary R Hime, Terence Y Pang, Department of Anatomy and Physiology, The University of Melbourne, Parkville 3010, VIC, Australia
Sophie LA Stonehouse, Terence Y Pang, Mental Health Theme, The Florey Institute of Neuroscience and Mental Health, Parkville 3052, VIC, Australia
Author contributions: Stonehouse SLA, Hime GR and Pang TY prepared the initial draft; Pang TY and Hime GR edited and reviewed the final manuscript.
Conflict-of-interest statement: The authors declare no conflict of interests.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Terence Y Pang, PhD, Senior Postdoctoral Fellow, Mental Health Theme, The Florey Institute of Neuroscience and Mental Health, 30 Royal Parade, Parkville 3052, VIC, Australia.
Received: February 24, 2021
Peer-review started: February 24, 2021
First decision: July 4, 2021
Revised: July 19, 2021
Accepted: August 25, 2021
Article in press: August 25, 2021
Published online: October 19, 2021
Core Tip

Core Tip: Psychiatry research is only beginning to identify the complex epigenetic pathologies across various conditions that may regulate symptomatology. Epigenetics may account for certain conditions that are highly heritable but are not fully accounted for by genetics. Preclinical animal models are a necessary tool to accelerate our understanding of molecular mechanisms and for developing new therapeutic options. Simple behavioural and neurobiological assays combined with high levels of functional gene conservation and rapid generation time in easily genetically manipulated organisms make Caenorhabditis elegans and Drosophila melanogaster excellent systems to model transgenerational epigenetic inheritance phenotypes.