Published online Oct 19, 2021. doi: 10.5498/wjp.v11.i10.711
Peer-review started: February 24, 2021
First decision: July 4, 2021
Revised: July 19, 2021
Accepted: August 25, 2021
Article in press: August 25, 2021
Published online: October 19, 2021
Core Tip: Psychiatry research is only beginning to identify the complex epigenetic pathologies across various conditions that may regulate symptomatology. Epigenetics may account for certain conditions that are highly heritable but are not fully accounted for by genetics. Preclinical animal models are a necessary tool to accelerate our understanding of molecular mechanisms and for developing new therapeutic options. Simple behavioural and neurobiological assays combined with high levels of functional gene conservation and rapid generation time in easily genetically manipulated organisms make Caenorhabditis elegans and Drosophila melanogaster excellent systems to model transgenerational epigenetic inheritance phenotypes.