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Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatr. Oct 19, 2021; 11(10): 696-710
Published online Oct 19, 2021. doi: 10.5498/wjp.v11.i10.696
Metabolic disturbances associated with antipsychotic drug treatment in patients with schizophrenia: State-of-the-art and future perspectives
Shen-Chieh Chang, Kah Kheng Goh, Mong-Liang Lu
Shen-Chieh Chang, Kah Kheng Goh, Mong-Liang Lu, Department of Psychiatry, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan
Kah Kheng Goh, Mong-Liang Lu, Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical University, Taipei 116, Taiwan
Author contributions: Chang SC and Goh KK contributed equally to this work; Chang SC, Goh KK, and Lu ML performed the literature search and reviewed the selected manuscripts; Chang SC wrote the first draft; Goh KK and Lu ML contributed to the final version of the manuscript; All authors have read and approve the final manuscript.
Supported by the Higher Education Sprout Project of the Ministry of Education, No. DP2-109-21121-01-N-07-04; and the Ministry of Science and Technology, No. MOST109-2314-B-038-083.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mong-Liang Lu, MD, MS, Professor, Department of Psychiatry, Wan Fang Hospital, Taipei Medical University, No. 111 Section 3, Hsin-Long Rd, Taipei 116, Taiwan. mongliang@hotmail.com
Received: January 30, 2021
Peer-review started: January 30, 2021
First decision: March 8, 2021
Revised: March 16, 2021
Accepted: August 31, 2021
Article in press: August 31, 2021
Published online: October 19, 2021
Core Tip

Core Tip: Metabolic disturbances associated with antipsychotic drug treatment are prevalent in patients with schizophrenia. We herein discuss the epidemiology, the underlying mechanisms, monitoring, and intervention strategies of antipsychotics related metabolic disturbances.