World J Psychiatry. Apr 19, 2022; 12(4): 615-622 Published online Apr 19, 2022. doi: 10.5498/wjp.v12.i4.615
Lidocaine in fibromyalgia: A systematic review
Jozélio Freire de Carvalho, Thelma L Skare
Jozélio Freire de Carvalho, Health Sciences Institute, Federal University of Bahia, Salvador 40231-300, Brazil
Thelma L Skare, Rheumatology Unit, Evangélico Mackenzie Hospital, Curitiba 80730-420, Brazil
Author contributions: de Carvalho JF and Skare TL contributed equally to this work; de Carvalho JF and Skare TL designed the research study, performed the research, and analyzed the data and wrote the manuscript; all authors have read and approved the final manuscript.
Conflict-of-interest statement: The authors declare no conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Corresponding author: Jozélio Freire de Carvalho, MD, PhD, Adjunct Professor, Health Sciences Institute, Federal University of Bahia, Rua das Violetas, 42, ap. 502, Salvador 40231-300, Brazil. jotafc@gmail.com
Received: March 19, 2021 Peer-review started: March 19, 2021 First decision: May 5, 2021 Revised: May 15, 2021 Accepted: February 23, 2022 Article in press: February 23, 2022 Published online: April 19, 2022 Processing time: 390 Days and 6.9 Hours
ARTICLE HIGHLIGHTS
Research background
Lidocaine is used to treat fibromyalgia patients.
Research motivation
As there are some articles that evaluated the role of lidocaine as therapy of fibromyalgia patients, the authors thought it is important to systematically review this literature.
Research objectives
The authors had the objective to perform the first systematic review on lidocaine in the treatment of fibromyalgia.
Research methods
Systematic review based on PRISMA guidelines and PROSPERO register.
Research results
Most studies showed reduction of pains measured by visual analogic scale after lidocaine infusion.
Research conclusions
This systematic review showed that lidocaine is effective and safe for fibromyalgia treatment, mainly in short-term.
Research perspectives
Future studies with large number of participants to evaluate the safety and efficacy of lidocaine for fibromyalgia is needed, as short and long-term studies.
