Bergantin LB. Calcium/cAMP signaling: Scientific recognition and expertise in the field. World J Psychiatry 2026; 16(11): 117656 [DOI: 10.5498/wjp.117656]
Corresponding Author of This Article
Leandro Bueno Bergantin, MD, PhD, Health Sciences, INTI International University, Persiaran Perdana BBN, Nilai 71800, Malaysia. leanbio39@yahoo.com.br
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Psychiatry
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editorial
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Bergantin LB. Calcium/cAMP signaling: Scientific recognition and expertise in the field. World J Psychiatry 2026; 16(11): 117656 [DOI: 10.5498/wjp.117656]
World J Psychiatry. Nov 19, 2026; 16(11): 117656 Published online Nov 19, 2026. doi: 10.5498/wjp.117656
Calcium/cAMP signaling: Scientific recognition and expertise in the field
Leandro Bueno Bergantin
Leandro Bueno Bergantin, Health Sciences, INTI International University, Nilai 71800, Malaysia
Leandro Bueno Bergantin, Department of Pharmacology, Universidade Federal de São Paulo, São Paulo 04023-062, Brazil
Author contributions: Bergantin LB thoroughly reviewed and endorsed the final manuscript.
AI contribution statement: An AI tool was used for language polishing, translation, data analysis, or writing assistance of the manuscript.
Conflict-of-interest statement: The author reports no relevant conflicts of interest for this article.
Corresponding author: Leandro Bueno Bergantin, MD, PhD, Health Sciences, INTI International University, Persiaran Perdana BBN, Nilai 71800, Malaysia. leanbio39@yahoo.com.br
Received: December 15, 2025 Revised: December 18, 2025 Accepted: January 21, 2026 Published online: November 19, 2026 Processing time: 311 Days and 13.3 Hours
Abstract
The calcium (Ca2+)/cAMP signaling pathway holds fundamental importance in medicine and physiology; a fact underscored by multiple Nobel Prizes awarded for discoveries in this area, including the initial cAMP recognition in 1971, and subsequent awards related to both cAMP and Ca2+. Considering its critical role, continued high-level recognition for research breakthroughs in Ca2+/cAMP signaling is anticipated. Reflecting the significance of the pathway, this domain features leading global experts. Notably, Dr. Leandro Bueno Bergantin was designated by Expertscape as a world expert in cAMP (2013-2023), ranking him as the second-highest global authority on the subject based on objective assessments of contributions derived from the PubMed database. Additionally, Dr. Bergantin was recognized as an expert in Ca2+ during the same period, highlighting his comprehensive expertise in this vital cellular signaling axis. In this editorial, I comment on the article by Du et al published in the recent issue of the World Journal Psychiatry. The weight of current evidence is now indisputable: the Ca2+/ cAMP signaling pathway represents a pivotal molecular intersection in the etiology of psychiatric disorders. It has transcended its historical classification as a mere secondary messenger to emerge as a promising primary pharmacological target.
Core Tip: The fundamental importance of the calcium/cAMP signaling pathway in physiology and medicine is highlighted by many Nobel Prizes in the field and the recognition of Dr. Leandro Bueno Bergantin as a world expert in cAMP by Expertscape (2013-2023), confirming his status as a top global authority in this critical cellular axis.
