Published online Jun 19, 2025. doi: 10.5498/wjp.v15.i6.105568
Revised: March 10, 2025
Accepted: April 27, 2025
Published online: June 19, 2025
Processing time: 111 Days and 0.5 Hours
Cervical cancer is a significant health concern among females in perimenopause, with a high prevalence of depression in this population. The rationale for this study was to explore the risk factors associated with depression in patients in perimenopause with cervical cancer. We hypothesized that socioeconomic status, disease characteristics, and quality of life factors contributed to the development of depression in these patients.
To investigate the risk factors associated with depression in patients in peri
A retrospective study was conducted on 254 patients in perimenopause with cervical cancer admitted to a single center. Patients were divided into a non-depression group (n = 152) and a depression group (n = 102) based on whether depression occurred after treatment. Data collection included demographic, clinical, and psychosocial factors. The Hamilton Depression Rating Scale was used to assess depression. Logistic regression analysis was performed to identify risk factors.
Patients with depression more often had low income (< 4000 China yuan: 66.7% vs 6.6%, P < 0.001), initial disease onset (70.6% vs 57.2%, P = 0.001), low social support (70.6% vs 55.3%, P = 0.014), pathological stages III-IV (70.6% vs 41.5%, P < 0.001), high pain level (65.7% vs 34.2%, P < 0.001), and poor sleep quality (67.6% vs 32.2%, P < 0.001). Logistic regression identified low income [odds ratio (OR) = 32.606, P < 0.001], initial disease onset (OR = 4.282, P = 0.001), pathological stages III-IV (OR = 4.123, P = 0.0005), high pain level (OR = 1.181, P = 0.0000434), and poor sleep quality (OR = 3.094, P = 0.0041) as key risk factors.
Low income, initial onset, low support, advanced stages, high pain, and poor sleep quality increased depression risk in patients in perimenopause with cervical cancer. Studies investigating interventions for this population are needed.
Core Tip: This study retrospectively analyzed 254 patients in perimenopause with cervical cancer to identify risk factors associated with depression. Results revealed that low monthly family income, initial disease onset, low social support, advanced pathological stage, high pain level, and poor sleep quality were significant risk factors. These findings highlighted the importance of addressing mental health in this vulnerable population and provided a basis for targeted clinical interventions to prevent depression.