Retrospective Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Jun 19, 2025; 15(6): 105568
Published online Jun 19, 2025. doi: 10.5498/wjp.v15.i6.105568
Risk factors for depression in patients in perimenopause with cervical cancer
Yuan Zhang, Jing-Bo Liu, Meng-Jun Liu, Jing Liu, Jing Zhang
Yuan Zhang, Jing-Bo Liu, Meng-Jun Liu, Jing Liu, Jing Zhang, Department of Gynecologic Oncology, The First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, Anhui Province, China
Author contributions: Zhang Y, Liu JB, Liu MJ, and Liu J contributed to the research design, data collection, data analysis, and paper writing; Zhang J was responsible for the funding application, reviewing and editing, communication coordination, ethical review related to the study, copyright and licensing issues, and follow-up activities; Zhang J served as the corresponding author, facilitating communication and overseeing the submission process; All authors read and approved the final manuscript.
Supported by Natural Science Key Research Project of Bengbu Medical University, No. 2021byzd098.
Institutional review board statement: The research was reviewed and approved by The First Affiliated Hospital of Bengbu Medical University on December 6, 2024.
Informed consent statement: All research participants or their legal guardians provided written informed consent prior to study registration.
Conflict-of-interest statement: All authors reported no relevant conflicts of interest for this article.
Data sharing statement: No other data available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jing Zhang, Associate Chief Physician, Department of Gynecologic Oncology, The First Affiliated Hospital of Bengbu Medical University, No. 287 Changhuai Road, Bengbu 233004, Anhui Province, China. zhangjing163127@163.com
Received: February 7, 2025
Revised: March 10, 2025
Accepted: April 27, 2025
Published online: June 19, 2025
Processing time: 111 Days and 0.5 Hours
Abstract
BACKGROUND

Cervical cancer is a significant health concern among females in perimenopause, with a high prevalence of depression in this population. The rationale for this study was to explore the risk factors associated with depression in patients in perimenopause with cervical cancer. We hypothesized that socioeconomic status, disease characteristics, and quality of life factors contributed to the development of depression in these patients.

AIM

To investigate the risk factors associated with depression in patients in perimenopause with cervical cancer.

METHODS

A retrospective study was conducted on 254 patients in perimenopause with cervical cancer admitted to a single center. Patients were divided into a non-depression group (n = 152) and a depression group (n = 102) based on whether depression occurred after treatment. Data collection included demographic, clinical, and psychosocial factors. The Hamilton Depression Rating Scale was used to assess depression. Logistic regression analysis was performed to identify risk factors.

RESULTS

Patients with depression more often had low income (< 4000 China yuan: 66.7% vs 6.6%, P < 0.001), initial disease onset (70.6% vs 57.2%, P = 0.001), low social support (70.6% vs 55.3%, P = 0.014), pathological stages III-IV (70.6% vs 41.5%, P < 0.001), high pain level (65.7% vs 34.2%, P < 0.001), and poor sleep quality (67.6% vs 32.2%, P < 0.001). Logistic regression identified low income [odds ratio (OR) = 32.606, P < 0.001], initial disease onset (OR = 4.282, P = 0.001), pathological stages III-IV (OR = 4.123, P = 0.0005), high pain level (OR = 1.181, P = 0.0000434), and poor sleep quality (OR = 3.094, P = 0.0041) as key risk factors.

CONCLUSION

Low income, initial onset, low support, advanced stages, high pain, and poor sleep quality increased depression risk in patients in perimenopause with cervical cancer. Studies investigating interventions for this population are needed.

Keywords: Cervical cancer; Perimenopause; Depression; Social support; Risk factors

Core Tip: This study retrospectively analyzed 254 patients in perimenopause with cervical cancer to identify risk factors associated with depression. Results revealed that low monthly family income, initial disease onset, low social support, advanced pathological stage, high pain level, and poor sleep quality were significant risk factors. These findings highlighted the importance of addressing mental health in this vulnerable population and provided a basis for targeted clinical interventions to prevent depression.