Published online Jun 19, 2020. doi: 10.5498/wjp.v10.i6.125
Peer-review started: December 30, 2019
First decision: March 24, 2020
Revised: April 17, 2020
Accepted: April 24, 2020
Article in press: April 24, 2020
Published online: June 19, 2020
A spectrum of neuropsychiatric disorders is a common complication from stroke. Neuropsychiatric disorders after stroke have negative effects on functional recovery, increasing the rate of mortality and disability of stroke survivors. Given the vital significance of maintaining physical and mental health in stroke patients, neuropsychiatric issues after stroke have raised concerns by clinicians and researchers. This mini-review focuses on the most common non-cognitive functional neuropsychiatric disorders seen after stroke, including depressive disorders, anxiety disorders, post-traumatic stress disorder, psychosis, and psychotic disorders. For each condition, the clinical performance, epidemiology, identification of the therapeutic implication, and strategies are reviewed and discussed; the main opinions and perspectives presented here are based on the latest controlled studies, meta-analysis, or updated systematic reviews. In the absence of data from controlled studies, consensus recommendations were provided accordingly.
Core tip: The purpose of this mini-review is to summarize the research advance of neuropsychiatric disorders including depressive disorders after stroke, anxiety disorders after stroke, post-traumatic stress disorder after stroke, post-stroke psychosis, and psychotic disorders. Recent evidence showed that neuropsychiatric disorders after stroke are associated with worsened outcomes yet are still under-recognized. With the exception of depressive disorders after stroke, the other neuropsychiatric disorders lack reliable and high-quality evidence in clinical practice. Further studies should attempt to develop protocols or guidelines for the diagnosis, treatment, or prevention of neuropsychiatric disorders after stroke.