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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Contribution of miRNAs to ion-channel remodelling in atrial fibrillation
José Manuel Vilches, Diego Franco, Amelia E Aránega, Cardiac and Skeletal Myogenesis Group, Department of Experimental Biology, University of Jaén, 23071 Jaén, Spain
Author contributions: All the authors equally contributed to this work.
Supported by Grants BFU2012-38111 (Ministerio de Economíay Competitividad, Gobierno de España), Nos. CTS-1614, P08-CTS-03878, BIO-302 (Junta de Andalucia) and AFM2012-16074 (AFM).
Conflict-of-interest: The authors declare that they have no competing interests.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Amelia E Aránega, PhD, Cardiac and Skeletal Myogenesis Group, Department of Experimental Biology, University of Jaén, CU Las Lagunillas B3-362, 23071 Jáen, Spain. aaranega@ujaen.es
Telephone: +34-953-212763 Fax: +34-953-211875
Received: October 7, 2014
Peer-review started: October 8, 2014
First decision: November 1, 2014
Revised: November 12, 2014
Accepted: December 10, 2014
Article in press: December 10, 2014
Published online: February 23, 2015
Peer-review started: October 8, 2014
First decision: November 1, 2014
Revised: November 12, 2014
Accepted: December 10, 2014
Article in press: December 10, 2014
Published online: February 23, 2015
Core Tip
Core tip: Atrial fibrillation (AF) is the most common sustained arrhythmia in clinical practice associated with pronounced mortality and morbidity. MicroRNAs (miRNAs), which are approximately 22 nucleotide long RNA regulators of gene expression, have become a major focus of research in molecular biology miRNAs have emerged as key post-transcriptional regulators of gene expression therefore, it is important to comment on the roles of these small non-protein-coding mRNAs in the cardiovascular system and their involvement in AF. In this review, we summarize the mechanism of miRNAs as regulators of ion-channels genes and their role in electrical remodelling caused by AF.